Fig. 3

Intervention impacts I from the Ross/Macdonald semi-analytic theory (top) and openmalaria (bottom) as a function of transmission intensity. In the upper panel, the solid lines show the impacts for the MDA and IRS alone, and together, when synchronously deployed. A dashed line indicates the impact of an IRS and MDA when applied temporally in isolation, consisting of the sum of the two isolated campaigns. Synchronous deployment far exceeds this impact, and may be understood mechanistically in Fig. 2, where the initial cleansing of the host reservoir from an MDA is maintained by the IRS. In the lower panel, openmalaria simulations show the same trends, though impacts are mostly greater since the recovery times post-intervention boost their effective duration. For each \(R_0\), eight simulations were run and their impacts plotted, though for most intensities the overlap is significant compared with the point-size. The connecting lines are drawn to guide the eye, and are used to interpolate the dashed profile for the isolated MDA + IRS, in accordance with the upper panel. One apparent contrast is the very weak IRS in openmalaria compared to the semi-analytic model. All interventions have 85% coverage, as before