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Table 4 Amino acid sequences of proposed peptides, their predicted binding affinity values (ΔG—kcalmol−1) and dissociation constant (Kd) with individual catalytic domains of the different proteins studied

From: Comparing sequence and structure of falcipains and human homologs at prodomain and catalytic active site for malarial peptide based inhibitor design

Protein Peptide
1 2 3 4 5
ΔG Kd (M) ΔG Kd (M) ΔG Kd (M) ΔG Kd (M) ΔG Kd (M)
FP-2 − 11.8 2.2E−09 − 11.2 8.4E−09 − 8.1 1.2E−06 − 9 2.7E−07 − 11.4 4.4E−09
FP-3 − 12.2 1.2E−09 − 10.5 2.0E−08 − 9.6 9.4E−08 − 9.7 7.8E−08 − 12.3 8.8E−10
VP-2 − 11.0 8.3E−09 − 10.1 3.8E−08 − 12.3 8.8E−10 − 9.0 2.7E−07 − 10.9 1.1E−08
VP-3 − 11.7 2.7E−09 − 11.0 8.3E−09 − 9.9 5.7E−08 − 9.2 1.7E−07 − 11.8 2.1E−09
KP-2 − 12.7 4.7E−10 − 11.8 2.1E−09 − 6.7 1.3E−05 − 8.1 1.2E−06 − 10.6 1.8E−08
KP-3 − 11.8 2.1E−09 − 12.7 5.2E−10 − 9.3 1.4E−07 − 9.2 1.9E−07 − 12.7 5.2E−10
BP-2 − 11.5 3.7E−09 − 12.2 1.2E−09 − 10.9 9.9E−09 − 7.9 1.7E−06 − 11.7 2.7E−09
CP-2 − 11.9 2.2E−09 − 11.7 2.7E−09 − 8.7 3.9E−07 − 8.3 1.1E−07 − 12.7 4.7E−10
YP-2 − 11.7 2.7E−09 − 14.3 5.5E−11 − 12.4 7.9E−10 − 10.4 2.5E−08 − 9.3 1.5E−07
Cat-K − 13.9 6.3E−11 − 11.5 3.5E−09 − 11.9 2.0E−09 − 11.4 4.2E−09 − 8.3 1.1E−07
Cat-L − 12.2 1.0E−09 − 11.8 5.1E−09 − 12.3 9.7E−10 − 10.2 3.5E−08 − 8.7 9.2E−07
Cat-S − 10.4 2.4E−09 − 11.5 3.5E−09 − 12.4 7.7E−10 − 9.9 5.2E−08 − 8.6 4.8E−07
  1. Peptide 1NRFGDLSFEEFKKKYLNLKLFD, 2LTYHEFKNKYLSLRSSK, 3MTFEEFKQKYLTLKSKD, 4EFKKKYLTLK, 5EFKKKYLTLKSKD
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