Malaria Journal

Table 4 Amino acid sequences of proposed peptides, their predicted binding affinity values (ΔG—kcalmol⁻¹) and dissociation constant (K_d) with individual catalytic domains of the different proteins studied

From: Comparing sequence and structure of falcipains and human homologs at prodomain and catalytic active site for malarial peptide based inhibitor design

Protein	Peptide
	1		2		3		4		5
	ΔG	K_d (M)	ΔG	K_d (M)	ΔG	K_d (M)	ΔG	K_d (M)	ΔG	K_d (M)
FP-2	− 11.8	2.2E−09	− 11.2	8.4E−09	− 8.1	1.2E−06	− 9	2.7E−07	− 11.4	4.4E−09
FP-3	− 12.2	1.2E−09	− 10.5	2.0E−08	− 9.6	9.4E−08	− 9.7	7.8E−08	− 12.3	8.8E−10
VP-2	− 11.0	8.3E−09	− 10.1	3.8E−08	− 12.3	8.8E−10	− 9.0	2.7E−07	− 10.9	1.1E−08
VP-3	− 11.7	2.7E−09	− 11.0	8.3E−09	− 9.9	5.7E−08	− 9.2	1.7E−07	− 11.8	2.1E−09
KP-2	− 12.7	4.7E−10	− 11.8	2.1E−09	− 6.7	1.3E−05	− 8.1	1.2E−06	− 10.6	1.8E−08
KP-3	− 11.8	2.1E−09	− 12.7	5.2E−10	− 9.3	1.4E−07	− 9.2	1.9E−07	− 12.7	5.2E−10
BP-2	− 11.5	3.7E−09	− 12.2	1.2E−09	− 10.9	9.9E−09	− 7.9	1.7E−06	− 11.7	2.7E−09
CP-2	− 11.9	2.2E−09	− 11.7	2.7E−09	− 8.7	3.9E−07	− 8.3	1.1E−07	− 12.7	4.7E−10
YP-2	− 11.7	2.7E−09	− 14.3	5.5E−11	− 12.4	7.9E−10	− 10.4	2.5E−08	− 9.3	1.5E−07
Cat-K	− 13.9	6.3E−11	− 11.5	3.5E−09	− 11.9	2.0E−09	− 11.4	4.2E−09	− 8.3	1.1E−07
Cat-L	− 12.2	1.0E−09	− 11.8	5.1E−09	− 12.3	9.7E−10	− 10.2	3.5E−08	− 8.7	9.2E−07
Cat-S	− 10.4	2.4E−09	− 11.5	3.5E−09	− 12.4	7.7E−10	− 9.9	5.2E−08	− 8.6	4.8E−07

Peptide 1^{NRFGDLSFEEFKKKYLNLKLFD}, 2^{LTYHEFKNKYLSLRSSK}, 3^{MTFEEFKQKYLTLKSKD}, 4^EFKKKYLTLK, 5^{EFKKKYLTLKSKD}

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ISSN: 1475-2875

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