Skip to main content

Table 5 Peptide 5-catalytic domain residue interaction fingerprint

From: Comparing sequence and structure of falcipains and human homologs at prodomain and catalytic active site for malarial peptide based inhibitor design

Protein

Subsite

Non-subsite residues

S1

S2

S3

S1′

FP-2

Q279, C282, G283, C323

L327, I328, S392, L415, N416, A418, D477

N320, G325, G326

V395, S396, A400, H417, A418, N447, W449

K280, W286, R470, C285

FP-3

Q287, C290, G291, Y332

Y335, S400, P423, A426, E485

K327, N328

A402, A403, S404, A408, N424, H425, N455, W457

L289, C293, W294, N338

VP-2

Q282, G286, Y327

F330, I331, P418, N419, A421

Q322, N323, G328, G329

I396, A397, V398, A403, H420, N451

D282, F331, P332, Y351, E367, F389

VP-3

Q288, C291, G292, C332, D333

N336, I337, S401, P424, N425

G334, G335, N329

I402, C403, A404, N405, H426, W458

D287, K289, C294, D406, S423, S457, G459, K458, W462

KP-2

Q288, C291, G292, C332, D333

L336, I337, S401, P424, N425, A427, E486

N329, G333, G334

N403, A404, N405, T409, H426, N456, W458

K289, N290, A293, C294, W295, E382, N405, D406, S457

KP-3

Q274, C277, G278, C318, D319

F322, N387, T410, N411, E472

Q314, N3145, N316, G320, G321

I388, A389, V390, S391, A395, N442, W444

G275, S279, C280, P324, R325, E368, N387, D392, T409

BP-2

Q264, A268, C308, E309

I312, A377, A400, N401, A403

N304, N305, F306, G311

V378, G379, D381, H402, N432, W434

K266, A272, P314, Y334, E349, A367, I376

CP-2

Q267, C270, A271, E312

I315, L316, A380, A303, N404, A406

N307, N308, D309, G314

V381, G382, A383, S384, H405, N437

K265, W274, Q306, P337, K351

YP-2

C271, A272, D313

I316, L317, A381, A404, N405, A407

N308, N309, F310, G314

V382, G383, V384, A385, H406, N438

Q269, W275, F310, E353, I380

Cat-K

C136, G137

Y181, M182, A248, L274, N275, A277

G179

D250, A251, S252, H276

C139, W140, F186, Y224, F256, W302, E226

Cat-L

C135, N179

L182, A248, D275, G277

N175

I249, A251, L257, H276

P172, G224, A234, I263

Cat-S

C134, N179

F182, G249, V274, N275, F323

N175, K176, G180

R253, F258, W298

Y173, Y225, E227, P229, Y230

  1. Italics are residues forming hydrogen bonds with the peptide