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Fig. 4 | Malaria Journal

Fig. 4

From: Excess risk of preterm birth with periconceptional iron supplementation in a malaria endemic area: analysis of secondary data on birth outcomes in a double blind randomized controlled safety trial in Burkina Faso

Fig. 4

Seasonal patterns and birth outcomes. Seasonal trends by trial arm in a PTB; b SGA; c LBW; d chronic placental malaria; e chorioamnionitis and f CRP at ANC2 assessment. The upper row shows the proportion (with 95% confidence intervals) for PTB, SGA and LBW outcomes by month of birth, with the months May/June to September/October occurring in the rainy season, and the months November through April in the dry season. The shaded region (July–September) represents the main malaria transmission season [13]. The lower panel provides the seasonal patterns by trial arm for chronic placental malaria, chorioamnionitis grades 2 and 3, and log CRP concentration at ANC2. Error bars represent 95% CI. Significance tests for season and arm effects based on a sinusoidal model adjusting for bed net use and baseline MUAC: Pc is a test for a sinusoidal seasonal trend; Pa is a test for difference between arms adjusting for season (birth month); Pac is a test for an interaction between seasonality and arm

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