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Table 1 Baseline characteristics of nulliparae with birth assessments by intervention group

From: Excess risk of preterm birth with periconceptional iron supplementation in a malaria endemic area: analysis of secondary data on birth outcomes in a double blind randomized controlled safety trial in Burkina Faso

Characteristic Iron Control
Sample size 163 144
Demographic and socioeconomic
 Mean age, years [IQR] 17.0 [16.0–18.0] 17.0 [16.0–18.0]
 Age < 20, n (%) 145/163 (89) 134/144 (93)
 Age < 17, n (%) 62/163 (38) 65/144 (45)
 Reproductive Age, years [IQR] 4 [3–5] 3 [2–4]
 Ethnic Group Mossi, n (%) 159/163 (98) 141/144 (98)
 Religion
  Muslim 49/163 (30) 36/143 (25)
  Christian 97/163 (53) 66/143 (56)
 Traditional 27/163 (17) 41/143 (29)
 No education, n (%) 109/162 (67) 91/144 (63)
 Primary education, n (%) 34/162 (21) 22/144 (15)
 Lower and higher secondary, n (%) 19/162 (12) 31/144 (22)
 Literate, n (%) 45/161 (28) 46/143 (32)
 Occupation
  Studenta 41/163 (25) 39/144 (27)
  Trading 7/163 (4) 7/144 (5)
  Domestic 101/163 (62) 74/144 (51)
  Farmer 75/163 (46) 58/144 (40)
 Unmarried, n (%) 145/163 (89) 133/144 (92)
Bed net use to ANC1, %, median [IQR]b 63 [50–83] [2 missing] 67 [47–84] [1 missing]
Clinical
 Menarcheal, n (%) 155/163 (95) 133/144 (92)
 Sexually active, n (%) 67/163 (41) 48/144 (33)
 Height, cms [IQR] 160 [156–164] 159 [155–163]
 Weight, kg [IQR] 51.4 [47.8–54.7] 50.9 [46.7–55.5]
 BMI, kg/m2 [IQR] 20.0 [18.9–21.1] 20.2 [18.9–21.0]
 BMI < 18.5 kg/m2, n (%) 29/163 (18) 28/144 (19)
 MUAC, cms [IQR] 24.1 [22.9–25.2] 24.2 [22.8–25.4]
Iron biomarkers
 Median Plasma CRP, mg/l [IQR] 0.59 [0.25–1.62] [5 missing] 0.68 [0.24–1.70] [2 missing]
 CRP > 5 mg/l, n (%) 13/158 (8) 14/142 (10)
 CRP > 10 mg/l, n (%) 5/158 (3) 7/142 (5)
 Median ferritin, µg/l [IQR] 51.50 [28.00–78.75] [4 missing] 46.00 [24.00–85.00] [3 missing]
 Median sTfR, mg/l [IQR] 6.13 [5.06–7.63] [3 missing] 6.33 [5.22–8.31] [3 missing]
 Median sTfRr/log ferritin ratio 3.72 [2.89–5.25] [4 missing] 3.84 [2.84–5.83] [3 missing]
 Iron deficiency (adj ferritin), n (%)c 16/157 (10) [6 missing] 21/141 (15) [3 missing]
 Iron deficiency (sTfR/log ferritin), n (%)d 33/159 (21) [4 missing] 42/141 (30) [3 missing]
Antenatal care
 First study visit (ANC1) 149/163 (91) 137/144 (95)
 Second study visit (ANC2) 123/163 (76) 120/144 (83)
 Median total ANC visits [IQR]e 4.00 [3.00–5.00] 4.00 [3.00–5.00]
 Median IPTp doses, IQR 2.00 [1.00–2.00] 2.00 [2.00–2.00]
 ≥ One IPTp dose n/N (%) 153/163 (94) 140/144 (97)
 ≥ Two IPTp dose, n/N (%) 109/163 (67) 114/144 (79)
  1. IPTp Intermittent preventive treatment with sulfadoxine-pyrimethamine
  2. aDomestic labour and farming not mutually exclusive
  3. bBed net use is the percentage of weekly visits between enrolment and ANC1 where bed nets were reported being used the night before
  4. cFerritin < 15 μg/L if CRP < 10 mg/l, or ferritin < 70 μg/L if CRP ≥ 10 mg/l. Ranges for normal controls were: ferritin, 69.1–114.7 µg/l; sTfR, 4.2-5.9 mg/l; CRP, 5–8 mg/l
  5. dRatio of sTfR (mg/l) to log10 ferritin (µg/l) > 5.6
  6. eANC1, ANC2 and non-study ANC visits