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Table 3 C-reactive protein concentration at baseline, ANC1, or ANC2, for preterm/term or SGA/AGA outcomes

From: Excess risk of preterm birth with periconceptional iron supplementation in a malaria endemic area: analysis of secondary data on birth outcomes in a double blind randomized controlled safety trial in Burkina Faso

Parameter mg/l n Outcomea Difference or Relative riska (95% CI) P Adjusted difference or relative riskb (95% CI) P cadj
Term Preterm
Baseline
 Log CRP, ± SD 280 − 0.2 ± 0.7 − 0.09 ± 0.7 1.18 (0.85; 1.63) 0.32 1.20 (0.87; 1.65) 0.26
 CRP > 5, n/N (%) 280 20/221 (9) 6/59 (10) 1.11 (0.53; 2.33) 0.79 1.14 (0.55; 2.35) 0.74
 CRP > 10, n/N (%) 280 8/221 (4) 4/59 (7) 1.62 (0.70; 3.75) 0.31 1.65 (0.73; 3.74) 0.31
ANC1
 Log CRP, ± SD 282 0.6 ± 0.7 0.7 ± 0.7 1.28 (0.91; 1.80) 0.15 1.33 (0.94;1.89) 0.097
 CRP > 5, n/N (%) 282 104/223 (47) 36/59 (61) 1.59 (0.99; 2.54) 0.049 1.60 (1.00; 2.55) 0.044
 CRP > 10, n/N (%) 282 69/223 (31) 26/59 (44) 1.55 (0.99; 2.44) 0.062 1.63 (1.04; 2.56) 0.036
ANC2
 Log CRP, ± SD 239 0.5 ± 0.7 0.9 ± 0.6 2.11 (1.25; 3.58) 0.004 1.78 (1.05; 3.00) 0.023
 CRP > 5, n/N (%) 239 74/208 (36) 19/31 (61) 2.49 (1.26; 4.90) 0.007 2.06 (1.04; 4.10) 0.034
 CRP > 10, n/N (%) 239 49/208 (24) 12/31 (38) 1.84 (0.95; 3.58) 0.082 1.48 (0.75; 2.91) 0.26
Parameter mg/l n Outcomea Difference or relative riska (95% CI) P Adjusted difference or relative Riskb (95% CI) P cadj
AGA SGA
Baseline
 Log CRP, ± SD 271 − 0.2 ± 0.7 − 0.1 ± 0.7 1.06 (0.83; 1.35) 0.67 1.10 (0.86; 1.4) 0.51
 CRP > 5, n/N (%) 271 15/183 (8) 11/88 (13) 1.35 (0.83; 2.19) 0.27 1.37 (0.86; 2.17) 0.23
 CRP > 10 n/N (%) 271 7/183 (4) 5/88 (6) 1.30 (0.65; 2.61) 0.50 1.41 (0.76; 2.63) 0.37
ANC1
 Log CRP, ± SD 273 0.7 ± 0.7 0.4 ± 0.7 0.75 (0.60; 0.94) 0.012 0.77 (0.61; 0.96) 0.018
 CRP > 5, n/N (%) 273 103/185 (56) 33/88 (38) 0.60 (0.42; 0.87) 0.005 0.62 (0.44; 0.09) 0.009
 CRP > 10, n/N (%) 273 70/185 (38) 23/88 (26) 0.68 (0.46;1.03) 0.054 0.71 (0.47; 1.07) 0.086
ANC2
 Log CRP, ± SD 236 0.5 ± 0.7 0.6 ± 0.7 1.08 (0.83; 1.41) 0.58 1.10 (0.84; 1.44) 0.51
 CRP > 5, n/N (%) 236 61/155 (39) 32/81 (40) 1.00 (0.70; 1.44) 0.98 1.02 (0.70; 1.47) 0.92
 CRP > 10, n/N (%) 236 40/155 (26) 21/81 (26) 1.00 (0.67; 1.50) 0.98 1.02 (0.68; 1.54) 0.91
  1. Antenatal clinic visits: ANC1 scheduled at 13–16 weeks gestation; ANC2 at 33–36 weeks gestation
  2. AGA appropriate for gestational age, SGA small for gestational age
  3. aN(%) for categorical variables; mean ± SD for log(CRP)
  4. bRelative risk for the categorical variables; difference in log10 CRP
  5. cAdjusted for assessment month
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