|
Parameter mg/l
|
n
|
Outcomea
|
Difference or Relative riska (95% CI)
|
P
|
Adjusted difference or relative riskb (95% CI)
|
P
cadj
|
|---|
|
Term
|
Preterm
|
|---|
|
Baseline
|
|
Log CRP, ± SD
|
280
|
− 0.2 ± 0.7
|
− 0.09 ± 0.7
|
1.18 (0.85; 1.63)
|
0.32
|
1.20 (0.87; 1.65)
|
0.26
|
|
CRP > 5, n/N (%)
|
280
|
20/221 (9)
|
6/59 (10)
|
1.11 (0.53; 2.33)
|
0.79
|
1.14 (0.55; 2.35)
|
0.74
|
|
CRP > 10, n/N (%)
|
280
|
8/221 (4)
|
4/59 (7)
|
1.62 (0.70; 3.75)
|
0.31
|
1.65 (0.73; 3.74)
|
0.31
|
|
ANC1
|
|
Log CRP, ± SD
|
282
|
0.6 ± 0.7
|
0.7 ± 0.7
|
1.28 (0.91; 1.80)
|
0.15
|
1.33 (0.94;1.89)
|
0.097
|
|
CRP > 5, n/N (%)
|
282
|
104/223 (47)
|
36/59 (61)
|
1.59 (0.99; 2.54)
|
0.049
|
1.60 (1.00; 2.55)
|
0.044
|
|
CRP > 10, n/N (%)
|
282
|
69/223 (31)
|
26/59 (44)
|
1.55 (0.99; 2.44)
|
0.062
|
1.63 (1.04; 2.56)
|
0.036
|
|
ANC2
|
|
Log CRP, ± SD
|
239
|
0.5 ± 0.7
|
0.9 ± 0.6
|
2.11 (1.25; 3.58)
|
0.004
|
1.78 (1.05; 3.00)
|
0.023
|
|
CRP > 5, n/N (%)
|
239
|
74/208 (36)
|
19/31 (61)
|
2.49 (1.26; 4.90)
|
0.007
|
2.06 (1.04; 4.10)
|
0.034
|
|
CRP > 10, n/N (%)
|
239
|
49/208 (24)
|
12/31 (38)
|
1.84 (0.95; 3.58)
|
0.082
|
1.48 (0.75; 2.91)
|
0.26
|
|
Parameter mg/l
|
n
|
Outcomea
|
Difference or relative riska (95% CI)
|
P
|
Adjusted difference or relative Riskb (95% CI)
|
P
cadj
|
|---|
|
AGA
|
SGA
|
|---|
|
Baseline
|
|
Log CRP, ± SD
|
271
|
− 0.2 ± 0.7
|
− 0.1 ± 0.7
|
1.06 (0.83; 1.35)
|
0.67
|
1.10 (0.86; 1.4)
|
0.51
|
|
CRP > 5, n/N (%)
|
271
|
15/183 (8)
|
11/88 (13)
|
1.35 (0.83; 2.19)
|
0.27
|
1.37 (0.86; 2.17)
|
0.23
|
|
CRP > 10 n/N (%)
|
271
|
7/183 (4)
|
5/88 (6)
|
1.30 (0.65; 2.61)
|
0.50
|
1.41 (0.76; 2.63)
|
0.37
|
|
ANC1
|
|
Log CRP, ± SD
|
273
|
0.7 ± 0.7
|
0.4 ± 0.7
|
0.75 (0.60; 0.94)
|
0.012
|
0.77 (0.61; 0.96)
|
0.018
|
|
CRP > 5, n/N (%)
|
273
|
103/185 (56)
|
33/88 (38)
|
0.60 (0.42; 0.87)
|
0.005
|
0.62 (0.44; 0.09)
|
0.009
|
|
CRP > 10, n/N (%)
|
273
|
70/185 (38)
|
23/88 (26)
|
0.68 (0.46;1.03)
|
0.054
|
0.71 (0.47; 1.07)
|
0.086
|
|
ANC2
|
|
Log CRP, ± SD
|
236
|
0.5 ± 0.7
|
0.6 ± 0.7
|
1.08 (0.83; 1.41)
|
0.58
|
1.10 (0.84; 1.44)
|
0.51
|
|
CRP > 5, n/N (%)
|
236
|
61/155 (39)
|
32/81 (40)
|
1.00 (0.70; 1.44)
|
0.98
|
1.02 (0.70; 1.47)
|
0.92
|
|
CRP > 10, n/N (%)
|
236
|
40/155 (26)
|
21/81 (26)
|
1.00 (0.67; 1.50)
|
0.98
|
1.02 (0.68; 1.54)
|
0.91
|
- Antenatal clinic visits: ANC1 scheduled at 13–16 weeks gestation; ANC2 at 33–36 weeks gestation
- AGA appropriate for gestational age, SGA small for gestational age
- aN(%) for categorical variables; mean ± SD for log(CRP)
- bRelative risk for the categorical variables; difference in log10 CRP
- cAdjusted for assessment month
