Fig. 3

Expression profiles of differentially expressed genes (DEGs) in a comparison of patient groups 3 and 4 (n = 1493). The heat-map shows expression profile across five clinical isolates, generated from log2-transformed normalized read counts. Clustering in the y-axis dendrogram reflects similarity in profile between DEGs. Clustering in the x-axis dendrogram indicates the similarity of differential expression between patients. The heat-map is divided into five sectors based on y-axis clustering. For each sector, the results of enrichment analysis of Gene Ontology (GO) terms are shown on the right. GO terms with significant enrichment within a given heat-map sector are listed with their description, ontological category [i.e. biological process (BP), molecular function (MF), cellular compartment (CC)], frequency in the background gene set (‘size’) and incidence within the heat-map sector (‘count’). Significance threshold was p-value < 0.05 after Bonferroni correction