Skip to main content

Advertisement

Table 2 Clinical and parasitological characteristics for infants in CAIG and NCIG groups

From: Plasmodium falciparum merozoite surface antigen-specific cytophilic IgG and control of malaria infection in a Beninese birth cohort

  Malaria infection groupsa
Asymptomatic infection clearance without anti-malarial treatment group (CAIG) N = 53 Control group (NCIG) N = 183
Infections during the follow-up asymptomatic infections, no (%)
 No infection 0 121 (66)
 1 24 (45) 48 (26)
 2–3 29 (55) 13 (7)
 > 3 0 1 (0)
Symptomatic infections, no (%)
 No infection 6 (11) 0 (0)
 1 17 (32) 26 (14)
 2–3 18 (34) 102 (56)
 > 3 12 (23) 55 (30)
Parasite densityb in asymptomatic infections, median (IQR) 38.6 (6.2–143.9) 60.2 (6.4–168.8)
Parasite density in symptomatic infections, median (IQR) 255.7 (8.0–806.8) 180.3 (10.1–698.8)
Time until malaria attacks (days)c, median (25th–75th) 34 (26–47) 13.5 (6–31)
Environmental risk of exposure to malariad during the follow-up, median (25th–75th) 3.06 (2.15–4.60) 3.89 (2.54–5.70)
  1. aCAIG was composed by 53 infants with spontaneous clearance of at least one asymptomatic infection. Among these 53 infants, six never had febrile malaria during the follow-up while 47 also developed at least one malaria attack. Among the 168 asymptomatic infections, 88 and 80 respectively occurred in CAIG and NCIG during the whole follow-up. 64/88 were followed by a negative of thick blood smears in the time, 17/88 were followed by a malaria attacks and 7/88 occurred at the end of the follow-up for which it was not possible to determine the outcome. Concerning NCIG, 62/80 were followed by a malaria attacks and 18/80 occurred at the end of the follow-up for which it was not possible to determine the outcome
  2. bParasite density was expressed in number of Pf-infected red blood cells for 100 leucocytes
  3. cThe time expressed in days between the detection of asymptomatic infection and the occurrence of febrile malaria was higher in CAIG than NCIG. All infants (n = 30) with only one malaria infection were considered as not sufficiently exposed to belong to both groups and excluded
  4. dEnvironmental risk of exposure to malaria was estimated for each infant once a month. No significant difference of exposure to malaria was observed between infants from CAIG and NCIG (p = 0.11; Mann–Whitney test)