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Table 3 Factors associated with malarial infection from 6 to 18 months of age (univariate analysis with logistic mixed model)

From: Plasmodium falciparum merozoite surface antigen-specific cytophilic IgG and control of malaria infection in a Beninese birth cohort

Variables OR p CI 95%
Placental malaria 1.91 0.023 [1.09,3.34]
Multigravida 0.85 0.521 [0.52,1.38]
Prematurity 0.86 0.611 [0.50,1.50]
Maternal Hb level at delivery 0.94 0.347 [0.83,1.06]
IPTp intake 0.84 0.443 [0.53,1.31]
Ethnic groups*
 Fon 1.08 0.789 [0.60,1.95]
 Others 0.53 0.016 [0.32,0.89]
Low birth weight 0.87 0.637 [0.51,1.50]
Environmental risk 1.21 < 0.001 [1.16,1.27]
Female 1.22 0.251 [0.86,1.72]
Infant Hb level at birth 0.99 0.883 [0.91,1.08]
Nutritional status 1.59 0.056 [0.98,2.58]
HbAS 0.94 0.802 [0.62,1.44]
Bed net possession 0.76 0.138 [0.53,1.09]
Age (6 month at reference)
 9 1.90 0.001 [1.29,2.80]
 12 4.58 < 0.001 [3.11,6.75]
 15 6.04 < 0.001 [4.08,8.94]
Antibody
 IgG1 to AMA1 1.08 0.004 [1.02,1.14]
 IgG1 to MSP1 1.08 0.001 [1.03,1.14]
 IgG1 to MSP2 3D7 1.09 0.001 [1.03,1.15]
 IgG1 to MSP2 FC27 1.06 0.032 [1.00,1.12]
 IgG1 to MSP3 1.13 0.002 [1.05,1.22]
 IgG1 to GLURP R0 1.07 0.052 [0.99,1.14]
 IgG1 to GLURP R2 1.07 0.028 [1.00,1.14]
 IgG3 to AMA1 1.09 0.002 [1.04,1.17]
 IgG3 to MSP1 1.06 0.020 [1.01,1.13]
 IgG3 to MSP2 3D7 1.05 0.026 [1.00,1.11]
 IgG3 to MSP2 FC27 1.05 0.038 [1.00,1.11]
 IgG3 to MSP3 1.10 0.007 [1.02,1.18]
 IgG3 to GLURP R0 1.01 0.667 [0.94,1.10]
 IgG3 to GLURP R2 1.07 0.018 [1.01,1.15]
  1. Significant p values (p ≤ 0.10) are mentioned in italics
  2. OR: odds ratio; OR > 1: variables associated with higher risk of malarial infection from 6 to 18 months of age, OR < 1: variables associated with lower risk of malarial infection from 6 to 18 months of age, p: p-value, CI: confidence interval
  3. *Tori, Fon and other less represented ethnic groups (Aïzo, Yoruba) were present in the study area: Tori were used as the reference group in the analysis. In the present analysis, the level of IgG1 and IgG3 quantified at each plasma collection (6, 9, 12 and 15 month of age) was correlated with malarial infection in the following trimester. Similar results were obtained when analysis was performed using data for symptomatic infections only