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Fig. 1 | Malaria Journal

Fig. 1

From: Competing risk events in antimalarial drug trials in uncomplicated Plasmodium falciparum malaria: a WorldWide Antimalarial Resistance Network individual participant data meta-analysis

Fig. 1

Situational competitiveness of newly emergent infections. Adapted from White-2002 [44]. The blue line represents a hypothetical drug concentration of partner component, the green and red lines represent scenarios for parasite burden versus time profiles following treatment for an infection where all the parasites are completely killed resulting in cure (green) and an infection where parasites are initially killed by high drug levels but with drug levels below the minimum inhibitory concentration (MIC), net parasite growth results in subsequent recrudescence (red). The orange line represents parasite-time profiles for a new infection. The left y-axis is for parasite density, and the right y-axis shows drug levels at hypothetical units. The vertical dotted line is the administrative end of the study follow-up. The horizontal dotted line represents the microscopic limit of detection for parasites. a Parasite population from a new inoculation out-competes the parasite population which caused the disease thus precluding recrudescence. In this situation, new infection is a biologically competing risk event. b In this situation new infection can be thought of as biologically competing risk event which doesn’t prevent recrudescence being observed. c The parasite population which caused the disease is completely eliminated. Here, new infection is not a competing event. d In this situation, the parasite population which caused the disease and which is derived from a novel inoculation appear at the same time

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