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Table 4 Diagnostic indices of the diagnostic techniques using sWGA assay as reference

From: Evaluating 18s-rRNA LAMP and selective whole genome amplification (sWGA) assay in detecting asymptomatic Plasmodium falciparum infections in blood donors

Technique

TP

TN

FP

FN

Sensitivity (95% CI)

Specificity (95% CI)

PPV (95% CI)

NPV (95% CI)

Microscopy

57

632

0

82

41.0

32.7–49.7

100

99.4–100.0

100

99.4–100.0

88.5

87.0–89.9

Rapid diagnostic test

91

632

0

48

65.5

56.9–73.3

100

99.4–100.0

100

99.4–100.0

92.9

91.3–94.3

crDNA-LAMP

129

614

1

27

82.6

75.8–88.3

99.8

99.1–100.0

99.2

94.8–99.9

95.8

94.2–97.0

pDNA-LAMP

133

630

2

6

95.7

90.1–98.4

99.7

98.8–99.9

98.5

94.3–99.6

99.1

97.9–99.6

  1. crDNA crude DNA extract, pDNA purified DNA extract, sWGA selective whole genome amplification, TP true positive, TN true negative, FP false positive, FN false negative, PPV positive predictive value, NPV negative predictive value