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Table 4 Diagnostic indices of the diagnostic techniques using sWGA assay as reference

From: Evaluating 18s-rRNA LAMP and selective whole genome amplification (sWGA) assay in detecting asymptomatic Plasmodium falciparum infections in blood donors

Technique TP TN FP FN Sensitivity (95% CI) Specificity (95% CI) PPV (95% CI) NPV (95% CI)
Microscopy 57 632 0 82 41.0
32.7–49.7
100
99.4–100.0
100
99.4–100.0
88.5
87.0–89.9
Rapid diagnostic test 91 632 0 48 65.5
56.9–73.3
100
99.4–100.0
100
99.4–100.0
92.9
91.3–94.3
crDNA-LAMP 129 614 1 27 82.6
75.8–88.3
99.8
99.1–100.0
99.2
94.8–99.9
95.8
94.2–97.0
pDNA-LAMP 133 630 2 6 95.7
90.1–98.4
99.7
98.8–99.9
98.5
94.3–99.6
99.1
97.9–99.6
  1. crDNA crude DNA extract, pDNA purified DNA extract, sWGA selective whole genome amplification, TP true positive, TN true negative, FP false positive, FN false negative, PPV positive predictive value, NPV negative predictive value