Anti-malarial drugs | Genes involved | Specific mutations | References |
---|---|---|---|
Artemisinins | |||
 Artemisinin and its derivatives | pfk13 | Confirmed/validated SNPs in the propeller domaina | |
4-Amino quinolones | |||
 Amodiaquine | pfcrt/pfmdr1 | pfmdr1: 86Y/Y184/1246Y | |
pfcrt codons 72-76 (CVIET/SVMNT) | |||
 Chloroquine | pfcrt/pfmdr1 | pfcrt codons 72-76 (CVIET/SVMNT) | |
pfmdr1: 86Y/Y184/1246Y | |||
 Mefloquine | pfmdr1 | Increased pfmdr1 CNV | |
Piperaquine | Plasmepsin 2/pfcrt | Increased pm2 CNV | |
pfcrt codons H95Y, F145I, M343L, G353L | |||
Antifolate drugs | |||
 Pyrimethamine | pfdhfr | pfdhfr: 51 I /59 R /108 N | |
 Sulfadoxine | pfdhps | pfdhps:436 A /437 G /540 E /581 G | |
Others | |||
 Lumefantrine | pfmdr1/pfcrt | pfmdr1:N86/184F/D1246 or increased CNV | |
pfcrt codons 72-76 (CVMNK) |