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Table 1 Sensitivity and precision of each pipeline (mean [95% CI])

From: Detection of low-density Plasmodium falciparum infections using amplicon deep sequencing

  DADA2 HaplotypR PASEC SeekDeep1x SeekDeep2x
All samples
 Sensitivity
  All 0.66 [0.62, 0.70] 0.66 [0.62, 0.70] 0.71 [0.68, 0.75] 0.72 [0.68, 0.76] 0.62 [0.56, 0.68]
  CSP 0.66 [0.61, 0.71] 0.64 [0.59, 0.70] 0.70 [0.64, 0.75] 0.70 [0.65, 0.75] 0.61 [0.53, 0.69]
  SERA2 0.65 [0.59, 0.70] 0.68 [0.62, 0.74] 0.73 [0.68, 0.78] 0.73 [0.68, 0.79] 0.63 [0.55, 0.71]
 Precision
  All 0.81 [0.77, 0.84] 0.88 [0.85, 0.90] 0.81 [0.78, 0.85] 0.25 [0.23, 0.27] 0.68 [0.63, 0.74]
  CSP 0.72 [0.67, 0.77] 0.94 [0.91, 0.97] 0.86 [0.81, 0.89] 0.26 [0.23, 0.28] 0.77 [0.69, 0.84]
  SERA2 0.91 [0.87, 0.94] 0.82 [0.78, 0.86] 0.77 [0.72, 0.82] 0.25 [0.22, 0.28] 0.61 [0.53, 0.68]
Samples with ≥ 100 reads
 Sensitivity
  All 0.83 [0.80, 0.86] 0.84 [0.81, 0.86] 0.83 [0.81, 0.86] 0.83 [0.80, 0.86] 0.78 [0.78, 0.87]
  CSP 0.82 [0.78, 0.86] 0.82 [0.77, 0.86] 0.82 [0.78, 0.86] 0.82 [0.78, 0.86] 0.84 [0.78, 0.89]
  SERA2 0.85 [0.80, 0.89] 0.86 [0.81, 0.90] 0.85 [0.80, 0.89] 0.85 [0.81, 0.89] 0.82 [0.75, 0.88]
Precision
  All 0.83 [0.80, 0.86] 0.89 [0.87, 0.92] 0.92 [0.90, 0.94] 0.26 [0.24, 0.28] 0.79 [0.74, 0.84]
  CSP 0.75 [0.70, 0.79] 0.94 [0.91, 0.96] 0.95 [0.92, 0.97] 0.27 [0.24, 0.30] 0.88 [0.83, 0.93]
  SERA2 0.92 [0.88, 0.95] 0.84 [0.80, 0.88] 0.90 [0.86, 0.93] 0.25 [0.22, 0.28] 0.71 [0.63, 0.78]