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Fig. 6 | Malaria Journal

Fig. 6

From: A non-lethal malarial infection results in reduced drug metabolizing enzyme expression and drug clearance in mice

Fig. 6

Effects of P. chabaudi infection on P450 protein levels in mouse livers. A new experiment was conducted, in which mice were euthanized 6, 8 and 12 days after infection with P. chabaudi and their livers analysed by Western blotting with IR dye detection. Values are mean ± SD, and expression in naive mice (day 0) was set at 1. The upper panel shows the Western blot images, with the Gapdh signal only shown for Cyp2b to conserve space. The lower panel shows the quantitation of these signals, normalized to Gapdh. Differences in mRNA expression between control and infected mice among the groups were analysed by MANOVA with Bonferroni corrected one-way ANOVAs as a post hoc test. *P < 7.14e−03, **P < 3.57e−03, ***P < 7.14e−04, significantly different from naïve group, n = 3 for all groups

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