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Fig. 8 | Malaria Journal

Fig. 8

From: A non-lethal malarial infection results in reduced drug metabolizing enzyme expression and drug clearance in mice

Fig. 8

Pharmacokinetic profiles in naïve and infected mice after cassette drug dosing. 8 days after P. chabaudi infection, 5 naïve and 5 infected mice were administered a cocktail of 5 drugs and blood was collected at the indicated times. Drug concentrations in the blood were measured by HILIC/MS. The plots show the mean blood concentrations ± SD in each group at each time point. a Caffeine; b bupropion; c tolbutamide; d midazolam; e bufuralol

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