Drug | Metabolism outcome | Enzymes involved | References |
---|---|---|---|
Artemisinin | Inactivation | CYP2B6, 3A4, 2D6 | |
Dihydroartemisinin (DHA) | Inactivation | UGT1A9, 2B7 | [49] |
Artesunate | DHA formation | CYP2A6 | [47] |
Arteether | DHA formation | CYP3A4>2B6,3A5 | [50] |
Artemether | DHA formation | CYP3A4 | [51] |
Quinine | Inactivation | CYP3A4 | |
Mefloquine | Inactivation | CYP3A4 | [52] |
Chloroquine | Active metabolite | CYP2C8, 3A4>2D6 | [53] |
Piperaquine | Active metabolite | CYP3A4 | [54] |
Primaquine | Required for activity | CYP2D6 | [55] |
Tafenoquine | Required for activity | CYP2D6 | [59] |
Lumefantrine | Inactivation | CYP3A4 | [51] |
Amodiaquine | Reduced activity | CYP2C8 | [56] |
Proguanil | Required for activity | CYP2C19 | [57] |
Sulfadoxine | Inactivation | NAT2 | [58] |
Clindamycin | Inactivation | CYP3A4 | [60] |