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Table 2 Important enzymes in the metabolism of anti-malarial drugs

From: A non-lethal malarial infection results in reduced drug metabolizing enzyme expression and drug clearance in mice

Drug

Metabolism outcome

Enzymes involved

References

Artemisinin

Inactivation

CYP2B6, 3A4, 2D6

[47, 48]

Dihydroartemisinin (DHA)

Inactivation

UGT1A9, 2B7

[49]

Artesunate

DHA formation

CYP2A6

[47]

Arteether

DHA formation

CYP3A4>2B6,3A5

[50]

Artemether

DHA formation

CYP3A4

[51]

Quinine

Inactivation

CYP3A4

[8, 47]

Mefloquine

Inactivation

CYP3A4

[52]

Chloroquine

Active metabolite

CYP2C8, 3A4>2D6

[53]

Piperaquine

Active metabolite

CYP3A4

[54]

Primaquine

Required for activity

CYP2D6

[55]

Tafenoquine

Required for activity

CYP2D6

[59]

Lumefantrine

Inactivation

CYP3A4

[51]

Amodiaquine

Reduced activity

CYP2C8

[56]

Proguanil

Required for activity

CYP2C19

[57]

Sulfadoxine

Inactivation

NAT2

[58]

Clindamycin

Inactivation

CYP3A4

[60]