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Table 1 Anti-malarial activity of basic blue 3 and ITT derivatives in vitro

From: In vitro and in vivo characterization of anti-malarial acylphenoxazine derivatives prepared from basic blue 3

  3D7 W2 MRA-1239 MRA-1240
IC50 (nM)a IC50 (nM)a IC50 (nM)a IC50 (nM)a
basic blue 3 3.2 ± 0.19 4.8 ± 0.53 5.2 ± 1.1 5.9 ± 0.68
ITT-001 11.2 ± 1.3 11.1 ± 1.8 34.6 ± 9.1 39.0 ± 11.2
ITT-002 10.7 ± 1.5 10.4 ± 2.8 20.7 ± 1.6 24.4 ± 3.7
ITT-003 9.8 ± 1.0 9.6 ± 2.1 24.9 ± 3.1 31.3 ± 9.8
ITT-004 11.3 ± 2.4 12.3 ± 2.7 26.4 ± 2.9 30.5 ± 2.0
ITT-005 138.3 ± 9.0 145.6 ± 29.5 130.2 ± 9.3 183.7 ± 30.1
ITT-006 10.6 ± 1.6 16.0 ± 4.5 27.5 ± 3.4 29.4 ± 5.8
CQ 8.6 ± 0.21 225.0 ± 23.2*** 38.6 ± 5.2 58.0 ± 2.6*
ART ND ND 5.5 ± 0.018 13.2 ± 1.4**
  1. IC50 concentration of 50% inhibition of parasite growth, SEM standard error of the mean, CQ chloroquine, ART artemisinin, ND not determine
  2. IC50s were compared between 3D7 and W2 strains and between MRA-1239 and MRA-1240 isolates (two-tailed unpaired Student’s t-test: * P < 0.05; ** P < 0.01; and *** P < 0.001)
  3. aData represent the mean ± SEM values for three experiments