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Table 2 Cytotoxicity and selective index (SI) of basic blue 3 and ITT derivatives in vitro

From: In vitro and in vivo characterization of anti-malarial acylphenoxazine derivatives prepared from basic blue 3

  HEK293T HepG2
CC50 (μM)a SI CC50 (μM)a SI
3D7 W2 MRA-1239 MRA-1240 3D7 W2 MRA-1239 MRA-1240
basic blue 3 0.021 ± 0.0042 6.6 4.4 4.0 3.6 1.0 ± 0.064 312.5 208.3 192.3 169.5
ITT-001 0.32 ± 0.042 28.6 28.8 9.2 8.2 4.0 ± 0.85 357.1 357.1 90.1 12.6
ITT-002 0.20 ± 0.021 18.7 19.2 9.7 8.2 > 50 > 4672.9 > 4807.7 > 2415.5 > 2049.2
ITT-003 9.2 ± 3.8 938.8 958.3 369.5 293.9 > 50 > 5102.0 > 5208.3 > 2008.0 > 1597.4
ITT-004 10.5 ± 3.4 929.2 853.7 397.7 344.3 > 50 > 4424.8 > 4065.0 > 1893.9 > 1639.3
ITT-005 0.73 ± 0.093 5.3 5.0 5.6 4.0 4.6 ± 0.26 33.2 31.6 35.3 25.0
ITT-006 13.6 ± 3.0 1283.0 850.0 494.5 462.6 > 50 > 3676.5 > 3125.0 > 1818.2 > 1700.7
CQ 2.9 ± 0.27 337.2 12.9 75.2 50.0 1.8 ± 0.14 209.3 8.0 46.6 31.0
  1. CC50 concentration of 50% cytotoxicity, SI selective index, CQ chloroquine
  2. aData represent the mean ± SEM values for three experiments