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Table 3 Anti-malarial activity of basic blue 3 and ITT derivatives in vivo

From: In vitro and in vivo characterization of anti-malarial acylphenoxazine derivatives prepared from basic blue 3

 

% suppression on day 4

MSD (day)

# of survived mice on day 30

basic blue 3a

> 99

20.3

1/4

ITT-001a

> 99

20.4

3/5

ITT-002a

> 99

19.2

2/5

ITT-003a

> 99

21.0

2/5

ITT-004a

> 99

29.4

4/5

ITT-005a

> 99

14.0

1/5

ITT-006a

91.5

13.0

0/5

ITT-004 (50)b

> 99

11.8

0/5

Control

c

6.5 ± 0.9d

0/5 (per group)

  1. MSD mean survival day
  2. aOrally administered to mice at a dose of 100 mg/kg
  3. bOrally administered to mice at a dose of 50 mg/kg
  4. cParasitaemia: 25.9 ± 5.8%d
  5. dMean ± SEM of representative three groups (see also Additional file 1: Fig. S7)