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Table 3 Anti-malarial activity of basic blue 3 and ITT derivatives in vivo

From: In vitro and in vivo characterization of anti-malarial acylphenoxazine derivatives prepared from basic blue 3

  % suppression on day 4 MSD (day) # of survived mice on day 30
basic blue 3a > 99 20.3 1/4
ITT-001a > 99 20.4 3/5
ITT-002a > 99 19.2 2/5
ITT-003a > 99 21.0 2/5
ITT-004a > 99 29.4 4/5
ITT-005a > 99 14.0 1/5
ITT-006a 91.5 13.0 0/5
ITT-004 (50)b > 99 11.8 0/5
Control c 6.5 ± 0.9d 0/5 (per group)
  1. MSD mean survival day
  2. aOrally administered to mice at a dose of 100 mg/kg
  3. bOrally administered to mice at a dose of 50 mg/kg
  4. cParasitaemia: 25.9 ± 5.8%d
  5. dMean ± SEM of representative three groups (see also Additional file 1: Fig. S7)