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Table 4 Mean fold change in relative expression of CYP6M2, CYP6P3, and GSTD3, and associated p values, between An. gambiae s.s. populations in the Faranah Prefecture and the An. gambiae s.s. susceptible G3 colony

From: Characterizing the molecular and metabolic mechanisms of insecticide resistance in Anopheles gambiae in Faranah, Guinea

   Permethrin 1× (R) Permethrin 1× (S) Permethrin 2× (R) Permethrin 2× (S) Permethrin 5× (R) Permethrin 5× (S) Permethrin 10× (S) Deltamethrin 1× (R) Deltamethrin 1× (S) Deltamethrin 2× (S) Deltamethrin 5× (S) Deltamethrin 10× (S) Bendiocarb 1× (R) Bendiocarb 1× (S) Bendiocarb 2× (R) Bendiocarb 2× (S) Bendiocarb 5× (R) Bendiocarb 5× (S) Bendiocarb 10× (R) Bendiocarb 10× (S) G3
CYP6M2 Exposed (n) 51 7 55 22 2 39 22 16 42 24 23 21 6 33 4 33 4 32 1 23 41
Mean fold change in gene expression 1.88 (0.70, 3.10) 0.74 (0.32, 1.08) 1.32 (0.76, 1.89) 0.57 (0.37, 0.78) 0.44 (−0.74, 1.61) 1.08 (0.73, 1.43) 1.65 (0.95, 2.35) 0.70 (0.49, 0.91) 0.92 (0.54, 1.30) 0.35 (0.26, 0.45) 2.50 (−1.86, 6.86) 0.41 (0.20, 0.62) 0.48 (0.07, 0.89) 0.41 (0.28, 0.54) 0.22 (0.05, 0.39) 0.54 (0.36, 0.73) 0.41 (−0.15, 0.98) 0.46 (0.24, 0.68) 1.03 0.59 (0.40, 0.78) 0.09 (0.07, 0.10)
Resistant v Susceptible p = 0.4792   p = 0.1035   p = 0.4131   p = 0.4804   p = 0.6586   p = 0.2988   p = 0.8824   
Wild v G3 p = 0.0077 p < 0 .0001 p = 0.0003 p < 0.0001 p < 0.0001 p < 0.0001 p < 0.0001 p < 0.0001 p < 0.0001 p < 0.0001 p = 0.1274 p < 0.0001 p < 0.0001 p < 0.0001 p < 0.0001 p < 0.0001 p < 0.0001 p = 0.0002 p < 0.0001  
CYP6P3 Exposed (n) 51 7 55 22 2 39 22 16 42 24 23 22 6 33 4 33 4 32 1 23 41
Mean fold change in gene expression 0.87 (0.44, 1.29) 0.72 (0.31, 1.00) 1.17 (0.39, 1.95) 0.91 (0.51, 1.32) 0.12 (−0.90, 1.14) 0.60 (0.38, 0.82) 0.43 (0.14, 0.72) 0.73 (0.15, 1.31) 0.45 (0.29, 0.61) 0.24 (0.17, 0.32) 1.05 (−0.77, 2.87) 0.29 (0.09, 0.49) 1.44 (0.07, 2.80) 0.62 (0.32, 0.92) 1.68 (−0.77, 4.13) 0.55 (0.26, 0.84) 1.50 (1.05, 1.95) 1.46 (−0.11, 3.04) 0.6 0.30 (0.18, 0.41) 0.12 (0.10, 0.15)
Resistant v Susceptible p = 0.8045   p = 0.6836   p = 0.3372   p = 0.1832   p = 0.0524   p = 0.0366   p = 0.9872   
Wild v G3 p = 0.0025 p < 0.0001 p = 0.022 p < 0.0001 p = 0.9417 p < 0.0001 p = 0.0047 p = 0.0007 p = 0.0001 p = 0.0003 p = 0.1605 p = 0.0261 p < 0.0001 p = 0.0004 p < 0.0001 p = 0.0013 p < 0.0001 p = 0.0534 p = 0.0002  
GSTD3 Exposed (n) 50 7 55 22 2 39 22 16 41 24 23 22 6 33 4 32 4 32 1 23 41
Mean fold change in gene expression 2.25 (1.19, 3.32) 1.14 (0.55, 1.45) 1.40 (0.90, 1.90) 0.87 (0.62, 1.11) 0.63 (−2.06, 3.30) 1.27 (0.68, 1.85) 1.47 (0.35, 2.59) 1.14 (0.84, 1.44) 1.29 (0.66, 1.93) 0.66 (0, 1.32) 2.01 (−1.57, 5.60) 0.36 (0.19, 0.53) 1.61 (0.28, 2.94) 1.07 (0.33, 1.80) 2.76 (−2.88, 8.40) 0.66 (0.41, 0.91) 1.09 (0.06, 2.11) 0.59(0.17, 1.00) 1.16 0.42 (0.31, 0.52) 0.44 (0.38, 0.51)
Resistant v Susceptible p = 0.4106   p = 0.1916   p = 0.6208   p = 0.7657   p = 0.5427   p = 0.1609   p = 0.4062   
Wild v G3 p = 0.0027 p < 0.0001 p = 0.0015 p < 0.0001 p = 0.2315 p = 0.0048 p = 0.0115 p < 0.0001 p = 0.0085 p = 0.3894 p = 0.2276 p = 0.2717 p < 0.0001 p = 0.0601 p < 0.0001 p = 0.0615 p < 0.0001 p = 0.4474 p = 0.6432  
  1. Italic values indicate significance of p values (p < 0.05)
  2. (R): resistant or alive; (S): susceptible