Table 2 Proportion of study participants with a reactive IgG, IgM or IgG subclass antibodies to P. falciparum antigens AMA-1 and GLURP-R0, according to HIV infection status
Recombinant malaria antigens | HIV negative (N = 52) | HIV positive (N = 129) | p valuea |
|---|---|---|---|
IgM-AMA1, n (%) | 7 (13) | 65 (50) | < 0.001 |
IgM-GLURP-R0, n (%) | 21 (40) | 94 (73) | < 0.001 |
IgG-AMA1, n (%) | 41 (79) | 115 (89) | 0.07 |
IgG-GLURP-R0, n (%) | 24 (46) | 71 (55) | 0.28 |
IgG1-AMA1, n (%) | 31 (60) | 117 (91) | < 0.001 |
IgG1-GLURP-R0, n (%) | 14 (27) | 90 (70) | < 0.001 |
IgG2-AMA1, n (%) | 6 (12) | 24 (19) | 0.25 |
IgG2-GLURP-R0, n (%) | 12 (23) | 30 (23) | 0.98 |
IgG3-AMA1, n (%) | 28 (54) | 114 (88) | < 0.001 |
IgG3-GLURP-R0, n (%) | 42 (81) | 124 (96) | 0.001 |
IgG4-AMA1, n (%) | 27 (52) | 63 (49) | 0.71 |
IgG4-GLURP-R0, n (%) | 1 (2) | 2 (2) | 0.86 |