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Table 2 Average parameters of P. falciparum susceptibility to chloroquine (CQ), quinine (QN), monodesethylamodiaquine (DQ), mefloquine (MQ), lumefantrine (LMF), pyronaridine (PND), piperaquine (PPQ), dihydroartemisinin (DHA), artesunate (AS) and doxycycline (DOX)

From: Low polymorphisms in pfact, pfugt and pfcarl genes in African Plasmodium falciparum isolates and absence of association with susceptibility to common anti-malarial drugs

Drugs

Isolates from Senegal (n = 86)

African isolates from imported malaria analyzed for pfcarl (n = 173)

IC50

Geometric mean

Resistance %

IC50

Geometric mean

Resistance %

Min

Max

Min

Max

CQ

0.6

954.9

60.0

48.6

6.27

791.6

69.7

28.3

QN

5

1429.8

113

5.7

5.29

690.1

127.8

0

DQ

1.6

227.3

21.7

23.6

1.9

196.43

29.2

8.1

MQ

2

109.2

24.8

48.5

4.4

173.43

39.5

67.7

LMF

0.5

82.9

4.53

0

0.33

16.66

1.4

0

PND

0.4

116.6

16.4

3.1

0.8

122.96

16.5

6.1

PPQ

3.2

241.9

37.4

6.1

0.94

137.51

34.3

0.6

DHA

0.08

17.28

1.36

1.5

0.09

28.11

4.1

17.5

AS

0.06

18.06

2.18

3.5

0.1

23.56

3.7

9.8

DOX

0.9

121.6

23.0

28.2

0.46

41.14

16.2

17.3

  1. IC50 in nM for CQ, QN, DQ, MQ, LMF, PND, PPQ, DHA, AS
  2. IC50 in µM for DOX