Table 3 Ex vivo susceptibility of African Plasmodium falciparum isolates to chloroquine (CQ), quinine (QN), monodesethylamodiaquine (DQ), mefloquine (MQ), lumefantrine (LMF), piperaquine (PPQ), pyronaridine (PND), dihydroartemisinin (DHA), artesunate (AS) and doxycycline (DOX) according to the K734M mutation in the pfcarl gene
Drug | Isolates from Senegal | African isolates from imported malaria | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Wild-type K734 (n = 61) | Mutated 734M (n = 6) | p-value | Wild-type K734 (n = 160) | Mutated 734 M (n = 13) | p-value | |||||
Mean IC50 | Min and Max | Mean IC50 | Min and Max | Mean IC50 | Min and Max | Mean IC50 | Min and Max | |||
CQ | 110.7 | 0.6/954.9 | 87.7 | 17.0/163 | 0.835 | 109.1 | 7.2/791.6 | 107.6 | 6.27/383.8 | 0.616 |
QN | 225.8 | 5/1429.8 | 69.0 | 15.0/140.1 | 0.087 | 176.0 | 11.53/690.1 | 137.8 | 5.29/338.3 | 0.227 |
DQ | 36.9 | 1.6/202.6 | 41.8 | 2.4/140.0 | 0.690 | 37.1 | 3.72/196.4 | 39.1 | 1.9/105.6 | 0.588 |
MQ | 37.6 | 2.0/123.0 | 19.6 | 10.0/44.0 | 0.088 | 48.8 | 4.4/173.4 | 60.0 | 21.16/172.6 | 0.398 |
LMF | 9.9 | 0.5/82.9 | 5.9 | 1.2/12.6 | 0.970 | 2.2 | 0.33/13.5 | 2.6 | 0.37/16.7 | 0.704 |
PPQ | 56.1 | 3.2/241.9 | 37.9 | 12.0/100.0 | 0.350 | 39.9 | 0.94/137.5 | 47.4 | 14.3/96.8 | 0.293 |
PND | 15.4 | 0.4/111.6 | 9.5 | 4.8/15.2 | 0.700 | 22.1 | 0.8/114.6 | 39.2 | 7.09/122.9 | 0.028 |
DHA | 2.9 | 0.8/17.3 | 2.1 | 0.09/9.2 | 0.101 | 6.0 | 0.19/28.1 | 7.1 | 0.09/23.3 | 0.404 |
AS | 4.2 | 0.06/18.1 | 4.6 | 2.5/8.5 | 0.709 | 5.0 | 0.1/23.6 | 5.8 | 1.9/17.9 | 0.362 |
DOX | 26.4 | 0.9/79.0 | 8.0 | 1.5/18.4 | 0.034 | 22.0 | 0.79/51.1 | 16.3 | 0.46/39.4 | 0.144 |