Fig. 3

Results of 2-compartment model fit. a Linear–linear plot of observed mean [ELQ-300] values at each timepoint (+ symbols) and values predicted from the curve fit (line). Estimated model parameters are shown in the insert table. Central = apparent volume of the central compartment (L); Cl_Central = central compartment clearance (L/h); ka_Central = rate constant for absorption; peripheral = apparent volume of the tissue compartment; Q12 = intercompartmental clearance (L/h). b Indicators of model fit validity: correspondence of observed and predicted values, unbiased distribution of residuals