Table 4 Performance of highly sensitive rapid diagnostic test by age

PCR prevalence

10.7%, 67/626

(8.3–13.1)

12.7%, 105/824

(10.5–15.2)

14.5%, 119/823

(12.1–16.9)

13.8%, 121/874

(11.6–16.1)

13.1, 81/619

(10.4–15.7)

Sensitivity

17.9%, 12/67

(8.7–27.1)

43.8%, 46/105

(34.3–53.3)

43.7%, 52/119

(34.8–52.6)

40.5%, 49/121

(31.7–49.2)

39.5%, 32/81

(28.9–50.2)

Specificity

93.0%, 520/5599

(90–95.1)

87.1%, 626/719

(84.6–89.5)

84.5%, 597/704

(81.8–87.6)

87.9%, 662/753

(85.6–90.3)

91.8%, 494/538

(89.5–94.1)

Positive predictive value

23.5%, 12/51

(11.9–35.2)

33.1%, 46/139

(25.3–40.9)

32.7%, 52/159

(25.4–39.9)

35.0%, 49/140

(27.1–42.9)

42.1%, 32/76

(31.0–53.2)

Negative predictive value

90.4%, 520/575

(88.03–92.8)

91.4%, 626/685

(89.3–93.4)

89.9%, 597/664

(87.6–92.2)

90.2%, 662/734 (88.03–92.3)

90.9%, 494/543

(88.6–93.4)

Comparison of HS-RDT sensitivity of older children and adults to children < 5 years

1

χ² = 12.3, p < 0.01

χ² = 12.6, p < 0.01

χ² = 10, p < 0.01

χ² = 8.2, p < 0.01