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Table 1 Characteristics of included studies

From: Impact of Plasmodium falciparum malaria and intermittent preventive treatment of malaria in pregnancy on the risk of malaria in infants: a systematic review

Author, year of publication. Country (references)

N

Study design

IPTp regimens

Follow-up duration

Measures of malaria in pregnancy

Measures of malaria during infancy

Maternal blooda

Placental bloodb

Placental histologyc

parasitaemia

Clinical malaria

Tassi Yunga, 2018. Cameroon [34]

80

Cohort

None

1 year

 

✓

 

✓

 

Boudova, 2017. Malawi [40]

473

RCT

SP vs CQ vs CQ prophylaxis

2 years

✓

✓

✓

✓

✓

Ruperez, 2016. Benin, Gabon, Tanzania, Mozambique [38]

4247

RCT

SP vs MQ

1 year

    

✓

Sylvester, 2016. Tanzania [41]

206

Cohort

Not reported

2 years

  

✓

✓

 

De Beaudrap, 2016. Uganda [37]

832

Cohort

SP

1 year

✓

✓

 

✓

 

Awine, 2016. Ghana [19]

988

RCT

SP vs ISTp-AL

1 year

  

✓

 

✓

Apinjoh, 2015. Cameroon [36]

415

Cohort

SP

1 year

✓

✓

✓

✓

 

Ndibazza, 2013. Uganda [39]

2289

Cohort

SP

5 years

✓

   

✓

Borgella, 2013. Benin [18]

194

Cohort

SP

1 year

✓

✓

 

✓

✓

Asante, 2013. Ghana [20]

1855

Cohort

SP

1 year

    

✓

Le Port, 2011. Benin [35]

550

Cohort

SP

1 year

 

✓

 

✓

 

Bardaji, 2011.Mozambique [16]

997

RCT

SP vs placebo

1 year

 

✓

✓

✓

 

Schwarz, 2008. Gabon [17]

527

Cohort

None

2.5 years

 

✓

  

✓

Mutabingwa, 2005. Tanzania [21]

453

Cohort

SP

1 year

 

✓

 

✓

 
  1. AL artemether lumefantrine, CQ chloroquine, IPTp intermittent preventive treatment of malaria in pregnancy, ISTp intermittent screening and treatment of malaria in pregnancy, MQ mefloquine, RCT randomized controlled trial, SP sulfadoxine–pyrimethamine
  2. aMalaria detected in maternal blood by microscopy or PCR
  3. bPlacental malaria detected in placental blood by microscopy
  4. cPlacental malaria detected in placental tissue by histology