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Table 1 DNA sequence polymorphism and tests of neutrality at PfAMA-1 among Plasmodium falciparum Bioko Island isolates

From: Natural selection and genetic diversity of domain I of Plasmodium falciparum apical membrane antigen-1 on Bioko Island

Fragment

Nt/bp

S

Total no. of mutations

K

H

Hd ± SD

π ± SD

dN − dS

Tajima’s D

Domain I

445–906

56

64

12.795

131

0.9911 ± 0.0017

0.02776 ± 0.00042

0.0327

0.56734 (P > 0.10)

C1

559–693

23

29

7.489

87

0.976 ± 0.003

0.05548 ± 0.00084

0.0641

1.49861 (P > 0.10)

C1L

586–621

15

18

4.469

52

0.937 ± 0.006

0.12413 ± 0.00214

0.1378

1.24277 (P > 0.10)

C2

724–735

6

6

1.421

11

0.777 ± 0.018

0.11840 ± 0.00490

0.1669

0.82057 (P > 0.10)

844–858

5

5

0.957

6

0.599 ± 0.031

0.06381 ± 0.00416

0.0834

0.26245 (P > 0.10)

C3

514–525

3

5

0.925

7

0.692 ± 0.020

0.07711 ± 0.00361

0.1018

0.19039 (P > 0.10)

  1. S segregating sites, K average number of pairwise nucleotide differences, H number of haplotypes, Hd haplotype diversity, π observed average pairwise nucleotide diversity, dN rate of non-synonymous mutations, dS rate of synonymous mutations
  2. * P < 0.05, ** P < 0.02