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Table 3 Inferred phenotype of CYP2D6 based on genotyping by treatment arm (%)

From: Pharmacokinetics/pharmacodynamics of chloroquine and artemisinin-based combination therapy with primaquine

CYP2D6 metabolism

AS

Phenotype

ASMQ

CQ

ALa

Normal

1.5 or 2

gNM-F

5

50.0%

9

90.0%

9

81.8%

≥ 2

gUM

1

 

0

 

0

 

Impaired

1

gNM-S

5

50.0%

0

10.0%

2

18.2%

0.5

gIM

0

 

1

 

0

 

0

gPM

1

 

0

 

0

 
  1. AS activity score, gNM-F normal-fast metabolizer, gUM ultrarapid metabolizer, gNM-S normal-slow metabolizer, gIM intermediate metabolizer, gPM poor metabolizer
  2. aCYP2D6 phenotype of two patients (ID 33 and 231) could not be defined