Fig. 6

Relationship between changes to CRP and haemoglobin level in volunteers from IBSM trial. a Haemoglobin levels following induced blood stage malaria infection. Generalized estimating equation (GEE) and Wilcoxon signed-rank nonparametric tests between each group are indicated. *p < 0.05; **p < 0.01. Data are presented in connecting lines with mean values and error bars indicating standard error. Dotted lines across the graph indicate mild-anaemia threshold for men and non-pregnant women. Correlations between CRPs expression on normocytes (b) and reticulocytes (c) and haemoglobin levels at day 8 and 45 following inoculation. Correlations between CRPs expression on normocytes (d) and reticulocytes (e) at day 10 and 17 and haemoglobin levels at day 11 and 22 following inoculation. Spearman’s nonparametric correlation test is indicated