Table 4 Patient history as well as signs and symptoms according to DARC 298A carriage and parasite species

No

757

152

521

112

69

13

167

27

Reported signs and symptoms in preceding 2 weeks

 Fever

99.6 (753/756)

100.0 (152)

99.6 (518/520)

100.0 (112)

100.0 (69)

100.0 (13)

99.4 (166)

100.0 (27)

 Headache

94.0 (711/756)

94.7 (144)

93.1 (484/520)

95.5 (107)

97.1 (67)

92.3 (12)

95.8 (160)

92.6 (25)

 Muscle pain

84.9 (642/756)

91.4 (139)*

84.2 (438/520)

92.0 (103)*

89.9 (62)

84.6 (11)

85.0 (142)

92.6 (25)

 Back pain

69.6 (526/756)

77.6 (118)*

67.9 (353/520)

77.7 (87)*

72.5 (50)

69.2 (9)

73.7 (123)

81.5 (22)

 Fatigue/weakness

86.1 (651/756)

92.8 (141)*

85.0 (442/520)

91.1 (102)

89.9 (62)

92.3 (12)

88.0 (147)

100.0 (27)

 Chills/shivering

88.1 (666/756)

90.1 (137)

88.1 (458/520)

90.2 (101)

82.6 (57)

84.6 (11)

90.4 (151)

92.6 (25)

 Sweats

73.5 (554/754)

77.6 (118)

76.1 (395/519)

73.2 (82)

65.2 (45)

92.3 (12)*

68.7 (114/166)

88.9 (24)*

 Cough

42.2 (319/756)

45.4 (69)

41.9 (218/520)

47.3 (53)

43.5 (30)

46.2 (6)

42.5 (71)

37.0 (10)

 Nausea

41.2 (311/754)

44.1 (67)

40.8 (212/519)

42.0 (47)

42.0 (29)

38.5 (5)

42.2 (70/166)

55.6 (15)

 Vomiting

29.8 (225/756)

29.6 (45)

28.5 (148/520)

22.3 (25)

30.4 (21)

69.2 (9)*

33.5 (56)

40.7 (11)

 Diarrhoea

3.3 (25/756)

6.6 (10)

2.9 (15/520)

8.9 (10)*

5.8 (4)

0.0 (0)

3.6 (6)

0.0 (0)

 Abdominal pain

31.7 (240/756)

29.6 (45)

30.0 (156/520)

32.1 (36)

40.6 (28)

23.1 (3)

33.5 (56)

22.2 (6)

Assessed parameters

 GMPD (/µl; 95% CI)

3364

3641

2995

3036

4681

11,580

4216

4428

(3011–3757)

(2800–4734)

(2626–3415)

(2253–4092)

(3148–6961)

(5055–26,527)

(3340–5321)

(2347–8354)

 Splenomegaly (%, n)

16.8 (126/751)

27.0 (41)*

14.5 (75/516)

25.9 (29)*

27.9 (19/68)

38.5 (5)

19.2 (32)

25.9 (7)

 Axillary temperature (°C, mean ± SD), n = 903

37.2 ± 1.6

37.4 ± 1.5

37.1 ± 1.6

37.3 ± 1.4

37.3 ± 1.7

37.4 ± 2.0

37.3 ± 1.5

38.1 ± 1.4*

 Body mass index (BMI) (kg/m²; median, range), n = 887

19.5 (12.2–46.3)

19.3 (13.6–33.3)

19.8 (12.3–39.5)

19.3 (13.6–33.3)

19.1 (12.6–27.5)

19.7 (14.6–24.9)

19.0 (12.2–46.3)

19.3 (16.7–31.9)

 Hypotension (systolic BP < 80 mm Hg; %, n)

1.6 (12/756)

2.0 (3)

1.0 (5/520)

1.8 (2)

1.4 (1)

0.0 (0)

3.6 (6)

3.7 (1)

 Severe thrombocytopenia (< 50,000/µl; %, n)

12.3 (88/715)

12.5 (18/144)

10.5 (52/495)

13.0 (14/108)

21.0 (13/62)

9.1 (1/11)

14.6 (23/158)

12.0 (3/25)

 Anaemia (%, n)

34.3 (248/722)

35.4 (52/147)

30.1 (151/501)

33.9 (37/109)

41.0 (25/61)

41.7 (5/12)

45.0 (72/160)

38.5 (10/26)

 Increased creatinine (> 1.4 mg/dl; %, n)

3.3 (23/688)

1.4 (2/140)

2.7 (13/473)

1.0 (1/103)

4.9 (3/61)

8.3 (1/12)

4.5 (7/154)

0.0 (0/25)

 Increased bilirubin (> 1.2 mg/dl; %, n)

46.8 (324/693)

56.1 (78/139)*

46.3 (221/477)

57.3 (59/103)*

53.3 (32/60)

50.0 (6/12)

45.5 (71/156)

54.2 (13/24)