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Table 1 Prevalence of pfcrt haplotypes, age distribution and msp1 genotyping result across regions

From: DNA recovery from archived RDTs for genetic characterization of Plasmodium falciparum in a routine setting in Lambaréné, Gabon

 

FGM

LA

RR

Total

N (%)

122 (18.2)

125 (18.7)

422 (61.3)

669

Age

 ≤ 5 years (%)

23 (18.8)

24 (19.2)

138 (32.7)

185 (27.7)

 ≥ 5 to 18 years (%)

80 (65.6)

58 (46.4)

208 (49.3)

346 (51.7)

Adults (> 18 years) (%)

19 (15.6)

43 (34.4)

76 (18.0)

138 (20.6)

pfcrt-PCR positivity (%)

109 (18.6)

108 (18.5)

368 (62.9)

585

CQ-sensitive (CVMNK) only (%)

21 (19.3)

37 (34.3)

68 (18.5)

126 (21.6)

CQ-resistance 1 (CVIET) only (%)

43 (39.4)

50 (46.3)

174 (47.3)

267 (45.6)

CQ-resistance 2 (SVMNT) (%)

0

0

0

0

Mix (R and S) (%)

45 (41.3)

21 (19.4)

126 (34.2)

192 (32.8)

msp1 PCR positivity (%)

111 (18.7)

107 (18.1)

374 (63.2)

592

Monoclonal infection

24 (21.6)

43 (40.2)

96 (25.7)

163 (27.5)

Polyclonal infection

87 (78.4)

64 (59.8)

278 (74.3)

429 (72.5)

K1 only

18

40

88

146

MAD20 only

10

15

31

56

RO33 only

11

14

39

64

K1 + MAD20

14

10

61

85

K1 + RO33

24

17

66

107

MAD20 + RO33

8

4

14

26

K1 + MAD20 + RO33

26

7

75

108

  1. Proportions of monoclonal and polyclonal infection were calculated within regions. Proportion of monoclonal infection in LA was significantly lower than that in the other two regions (df = 2, p-value = 0.004). Overall prevalence of CQ resistance (by summing up the prevalence of resistance and mix infection) was 65.7% in LA and 81.3% in rural regions (including FGM)
  2. R, chloroquine resistance; S, chloroquine sensitive; FGM, Fougamou; LA, Lambaréné; RR, rural regions; CQ, chloroquine