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Table 1 Prevalence of pfcrt haplotypes, age distribution and msp1 genotyping result across regions

From: DNA recovery from archived RDTs for genetic characterization of Plasmodium falciparum in a routine setting in Lambaréné, Gabon

  FGM LA RR Total
N (%) 122 (18.2) 125 (18.7) 422 (61.3) 669
Age
 ≤ 5 years (%) 23 (18.8) 24 (19.2) 138 (32.7) 185 (27.7)
 ≥ 5 to 18 years (%) 80 (65.6) 58 (46.4) 208 (49.3) 346 (51.7)
Adults (> 18 years) (%) 19 (15.6) 43 (34.4) 76 (18.0) 138 (20.6)
pfcrt-PCR positivity (%) 109 (18.6) 108 (18.5) 368 (62.9) 585
CQ-sensitive (CVMNK) only (%) 21 (19.3) 37 (34.3) 68 (18.5) 126 (21.6)
CQ-resistance 1 (CVIET) only (%) 43 (39.4) 50 (46.3) 174 (47.3) 267 (45.6)
CQ-resistance 2 (SVMNT) (%) 0 0 0 0
Mix (R and S) (%) 45 (41.3) 21 (19.4) 126 (34.2) 192 (32.8)
msp1 PCR positivity (%) 111 (18.7) 107 (18.1) 374 (63.2) 592
Monoclonal infection 24 (21.6) 43 (40.2) 96 (25.7) 163 (27.5)
Polyclonal infection 87 (78.4) 64 (59.8) 278 (74.3) 429 (72.5)
K1 only 18 40 88 146
MAD20 only 10 15 31 56
RO33 only 11 14 39 64
K1 + MAD20 14 10 61 85
K1 + RO33 24 17 66 107
MAD20 + RO33 8 4 14 26
K1 + MAD20 + RO33 26 7 75 108
  1. Proportions of monoclonal and polyclonal infection were calculated within regions. Proportion of monoclonal infection in LA was significantly lower than that in the other two regions (df = 2, p-value = 0.004). Overall prevalence of CQ resistance (by summing up the prevalence of resistance and mix infection) was 65.7% in LA and 81.3% in rural regions (including FGM)
  2. R, chloroquine resistance; S, chloroquine sensitive; FGM, Fougamou; LA, Lambaréné; RR, rural regions; CQ, chloroquine