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Table 3 Frequency and number of Pfmdr1 mutations in the populations sampled at Nnewi, Southeast Nigeria

From: Analysis of Plasmodium falciparum Pfcrt and Pfmdr1 genes in parasite isolates from asymptomatic individuals in Southeast Nigeria 11 years after withdrawal of chloroquine

Gene

Codon

Children

(n = 36)

Pregnant women

(n = 20)

Other adults (n = 26)

(Total n = 82)

Mutants n (%)

Mutants n (%)

Mutants n (%)

Mutant n (%)

Heterozygote n (%)

Pfmdr1

N86Y

6 (16.67)

1 (5.00)

0 (0.00)

7 (8.54)

0 (0.00)

 

Y158H

0 (0.00)

1 (5.00)

0 (0.00)

1 (1.22)

0 (0.00)

 

Y184F

14 (38.88)

4 (20.00)

6 (23.08)

24 (29.27)

3 (3.66)

 

F74L

1 (2.77)

0 (0.00)

0 (0.00)

1 (1.22)

0 (0.00)

 

S164S

1 (2.77)

0 (0.00)

0 (0.00)

1 (1.22)

0 (0.00)

 

K1104E

0 (0.00)

1 (5.00)

0 (0.00)

1 (1.22)

0 (0.00)

 

Y1004H

0 (0.00)

1 (5.00)

0 (0.00)

1 (1.22)

0 (0.00)

 

S1066P

0 (0.00)

0 (0.00)

0 (0.00)

0 (0.00)

1 (1.22)

 

T1069T

1 (2.77)

1 (0.00)

1 (3.85)

2 (2.44)

0 (0.00)

 

A1077A

1 (2.77)

2 (0.00)

0 (0.00)

1 (1.22)

0 (0.00)

 

A1090A

0 (0.00)

0 (0.00)

0 (0.00)

0 (0.00)

1 (1.22)

 

N1106S

1 (2.77)

0 (0.00)

0 (0.00)

1 (1.22)

0 (0.00)

 

I1117 V

1 (2.77)

1 (0.00)

0 (0.00)

1 (1.22)

0 (0.00)

 

R1176G

1 (2.77)

2 (0.00)

0 (0.00)

1 (1.22)

0 (0.00)

 

I1122T

1 (2.77)

3 (0.00)

0 (0.00)

1 (1.22)

0 (0.00)

 

K1129R

0 (0.00)

1 (5.00)

0 (0.00)

1 (1.22)

0 (0.00)

 

S1137S

1 (2.77)

0 (0.00)

0 (0.00)

1 (1.22)

0 (0.00)

 

D1246Y

2 (5.55)

1 (5.00)

0 (0.00)

3 (3.66)

0 (0.00)

 

G1114G

0 (0.00)

0 (0.00)

0 (0.00)

0 (0.00)

1 (1.22)

 

I1143 V

0 (0.00)

0 (0.00)

0 (0.00)

0 (0.00)

1 (1.22)

 

T1157T

0 (0.00)

0 (0.00)

1 (3.85)

1 (1.22)

0 (0.00)

 

K1154 K

0 (0.00)

1 (5.00)

0 (0.00)

1 (1.22)

0 (0.00)

 

T1224T

0 (0.00)

1 (5.00)

0 (0.00)

1 (1.22)

0 (0.00)

 

N1243 K

0 (0.00)

0 (0.00)

1 (3.85)

1 (1.22)

0 (0.00)

 

R1244G

0 (0.00)

1 (5.00)

0 (0.00)

1 (1.22)

0 (0.00)

Haplotypes

 

NFD n (%)

11 (30.56)

3 (15.00)

6 (23.08)

20 (24.39)

 

NFYn (%)

0 (0.00)

1 (5.00)

0 (0.00)

1 (1.22)

 

YFDn (%)

5 (13.89)

0 (0.00)

0 (0.00)

5 (6.10)

 

NYYn (%)

1 (2.78)

0 (0.00)

0 (0.00)

1 (1.22)

 
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Malaria Journal

ISSN: 1475-2875

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