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Table 3 Frequency and number of Pfmdr1 mutations in the populations sampled at Nnewi, Southeast Nigeria

From: Analysis of Plasmodium falciparum Pfcrt and Pfmdr1 genes in parasite isolates from asymptomatic individuals in Southeast Nigeria 11 years after withdrawal of chloroquine

Gene Codon Children
(n = 36)
Pregnant women
(n = 20)
Other adults (n = 26) (Total n = 82)
Mutants n (%) Mutants n (%) Mutants n (%) Mutant n (%) Heterozygote n (%)
Pfmdr1 N86Y 6 (16.67) 1 (5.00) 0 (0.00) 7 (8.54) 0 (0.00)
  Y158H 0 (0.00) 1 (5.00) 0 (0.00) 1 (1.22) 0 (0.00)
  Y184F 14 (38.88) 4 (20.00) 6 (23.08) 24 (29.27) 3 (3.66)
  F74L 1 (2.77) 0 (0.00) 0 (0.00) 1 (1.22) 0 (0.00)
  S164S 1 (2.77) 0 (0.00) 0 (0.00) 1 (1.22) 0 (0.00)
  K1104E 0 (0.00) 1 (5.00) 0 (0.00) 1 (1.22) 0 (0.00)
  Y1004H 0 (0.00) 1 (5.00) 0 (0.00) 1 (1.22) 0 (0.00)
  S1066P 0 (0.00) 0 (0.00) 0 (0.00) 0 (0.00) 1 (1.22)
  T1069T 1 (2.77) 1 (0.00) 1 (3.85) 2 (2.44) 0 (0.00)
  A1077A 1 (2.77) 2 (0.00) 0 (0.00) 1 (1.22) 0 (0.00)
  A1090A 0 (0.00) 0 (0.00) 0 (0.00) 0 (0.00) 1 (1.22)
  N1106S 1 (2.77) 0 (0.00) 0 (0.00) 1 (1.22) 0 (0.00)
  I1117 V 1 (2.77) 1 (0.00) 0 (0.00) 1 (1.22) 0 (0.00)
  R1176G 1 (2.77) 2 (0.00) 0 (0.00) 1 (1.22) 0 (0.00)
  I1122T 1 (2.77) 3 (0.00) 0 (0.00) 1 (1.22) 0 (0.00)
  K1129R 0 (0.00) 1 (5.00) 0 (0.00) 1 (1.22) 0 (0.00)
  S1137S 1 (2.77) 0 (0.00) 0 (0.00) 1 (1.22) 0 (0.00)
  D1246Y 2 (5.55) 1 (5.00) 0 (0.00) 3 (3.66) 0 (0.00)
  G1114G 0 (0.00) 0 (0.00) 0 (0.00) 0 (0.00) 1 (1.22)
  I1143 V 0 (0.00) 0 (0.00) 0 (0.00) 0 (0.00) 1 (1.22)
  T1157T 0 (0.00) 0 (0.00) 1 (3.85) 1 (1.22) 0 (0.00)
  K1154 K 0 (0.00) 1 (5.00) 0 (0.00) 1 (1.22) 0 (0.00)
  T1224T 0 (0.00) 1 (5.00) 0 (0.00) 1 (1.22) 0 (0.00)
  N1243 K 0 (0.00) 0 (0.00) 1 (3.85) 1 (1.22) 0 (0.00)
  R1244G 0 (0.00) 1 (5.00) 0 (0.00) 1 (1.22) 0 (0.00)
Haplotypes
  NFD n (%) 11 (30.56) 3 (15.00) 6 (23.08) 20 (24.39)  
NFYn (%) 0 (0.00) 1 (5.00) 0 (0.00) 1 (1.22)  
YFDn (%) 5 (13.89) 0 (0.00) 0 (0.00) 5 (6.10)  
NYYn (%) 1 (2.78) 0 (0.00) 0 (0.00) 1 (1.22)