Fig. 1

Broad protection goals given to participants as a starting point for discussion. The broad protection goals of human health, biodiversity, water quality, agriculture, animal health, soil quality, natural resources, and air quality are usually defined by statutes in most countries. The relative frequency with which particular protection goals were chosen for further consideration in the construction of pathways to harm is shown in the bar graphs for each protection goal. The bar graph is not meant to assign a ranking of importance of the protection goals, or represent quantitative data produced in the consultations. It is instead an anecdotal assessment intended to convey only a qualitative assessment of the protection goals identified by the participants prior to developing their pathways to harm. The protection goal category ‘Other’ was included to allow participants to create new protection goals not included in the starting point list. For this category, several groups chose socioeconomic protection goals (e.g., valuable services or products important to malaria prevention or cures or that might become less widely available should the introduction of a gene drive mosquito significantly decrease the incidence of malaria)