A Protection goal: human health | |||
---|---|---|---|
Harm: Increase in non‐malarial disease due to other vectors | |||
Step | Pathway to harm | Plausibility | Additional information needed |
1 | Introduction of the gene drive mosquito | Given | Literature review, including information/evidence from other control programmes that have eliminated An. gambiaea |
2 | Population of An. gambiae declines | Likely | |
3 | Ecological niche opens up providing room for the expansion of another vector population | Likely | |
4 | Increased possibility of disease transmission | Likely | |
5 | Other diseases increase (e.g. filariasis, arbovirus, etc.) | Likely |
B Protection goal: human health | |||
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Harm: The modification makes the mosquito capable of transmitting new pathogens, causing new diseases in humans | |||
Step | Pathway to harm | Plausibility | Additional information needed |
1 | Introduction of the gene drive mosquito | Given | Capability of mosquitoes to support the development of other pathogensb |
2 | The modification causes unintended effects due to pleiotropy | Unknown | |
3 | Pleiotropic effect renders mosquito capable of being a vector for new pathogens | Unknown | |
4 | New/unknown pathogens cause a new disease in humans | Unknown |