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Table 3 SMFA results for Pfs230C1 and Pfs230D1+ as tested in two immunization studies

From: The Pfs230 N-terminal fragment, Pfs230D1+: expression and characterization of a potential malaria transmission-blocking vaccine candidate

Name

Conc [μg/mL]

Mean oocyst

%TRA

(95% CI)

p-value

Immunization study #1

 Control

750.0

10.9

   

 C1 (5.0)

750.0

0.2

98.2

(95 to 100)

0.001

 C1 (0.5)

750.0

0.2

98.2

(95 to 100)

0.001

 C1 (0.05)

750.0

1.7

84.9

(65 to 94)

0.001

 D1+ (5.0)

750.0

0.2

98.2

(95 to 100)

0.001

 D1+ (0.5)

750.0

0.2

98.2

(95 to 100)

0.001

 D1+ (0.05)

750.0

0.4

96.8

(92 to 99)

0.001

Immunization study #2

 Control

750.0

39.2

   

 C1 (1.0)

750.0

0.5

98.9

(97 to 100)

0.001

 D1+ (1.0)

750.0

0.1

99.7

(99 to 100)

0.001

  1. Purified IgG samples were tested at 750 μg/mL by SMFA with complement. Mean oocyst number, % reduction of oocyst density (%TRA), the 95% confidence interval, and p-value of each test IgG are shown