Table 1 Sensitivity of different malaria tests as a factor of parasite density or antigen concentration

Parasite density thresholds (Pf p/μL)

 HRP2 RDT+

–

6.1 (2.1–11)

27.7 (12–53)

77.5 (31–177)

 Bead-based HRP2+

–

–

–

3.2 (1.5–130)

 Bead-based pAldo+

2.5 (1.5–6.7)

30.8 (12–60)

377.1 (147–1073)

2056 (520–8527)

 Bead-based pLDH+

18.3 (6.6–37)

266.1 (135–576)

3901 (1190–14,589)

–

Parasite density thresholds (Pf p/μL)

 Positivity to any one antigen

1.7 (1.3–2.2)

3.0 (2.2–4.4)

5.5 (3.3–8.5)

8.3 (4.1–13)

 Positivity to any two antigens

6.7 (4.5–9.8)

27.3 (18–42)

110.2 (60–190)

285.3 (130–540)

 Positivity to all three antigens

57.1 (37–87)

375.0 (224–648)

2464 (1119–5210)

8909 (3109–NA)

HRP2 concentration thresholds (HRP2 pg/mL)

 HRP2 RDT+

561.5 (305–899)

1609 (925–2472)

4548 (2438–7806)

9346 (4185–17,432)