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Fig. 4 | Malaria Journal

Fig. 4

From: Tamoxifen activity against Plasmodium in vitro and in mice

Fig. 4

Alternative strategy to study cerebral malaria in mouse models that require tamoxifen. CB57/B6 mice were treated with tamoxifen 40 mg/kg per day one week prior infection with 1 million (circles), 5 millions (squares) or 20 millions (triangles) P. berghei ANKA infected RBCs. During the course of the infection animals continued being treated with tamoxifen and parasitaemia levels were monitored showing no differences between groups (a). As an alternative approach to study cerebral malaria in mouse models that require the use of tamoxifen, CB57/B6 mice were randomized into 3 groups: control group without tamoxifen (circles), treated with tamoxifen for 1 week and then rested, without any further tamoxifen treatment, for 1 week (squares) or 2 weeks (triangles) before infection with 1 million P. berghei infected RBCs. All groups developed comparable levels of parasitaemia (b), developed neurological signs of cerebral malaria (c) and did not differ in survival (d)

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