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Fig. 2 | Malaria Journal

Fig. 2

From: The effects of dyslipidaemia and cholesterol modulation on erythrocyte susceptibility to malaria parasite infection

Fig. 2

Increasing the red cell membrane cholesterol content reduces Plasmodium falciparum invasion efficiency. a Representative flow cytometry profiles highlighting infected erythrocyte populations. Top panel includes negative control (erythrocytes only), and erythrocytes incubated with merozoites in the presence of the Plasmodium invasion inhibitor Cytochalasin D (CytD). b Quantification of P. falciparum invasion efficiency into MβCD-cholesterol pre-treated red cells. Values represent mean and standard deviation of triplicate wells. This effect on erythrocyte invasion was reproducible across different blood donors (c). P values comparing the treatment versus control were calculated using the Student’s t test (*p < 0.05; **p < 0.01)

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