Genetic profiling of the Plasmodium falciparum parasite population in uncomplicated malaria from India

Malaria Journal

Table 3 The distribution of haplotypes (A1–A18) based upon the mutation codon differentiation for Pfcrt, Pfmdr-1, Pfdhfr, Pfdhps and Pfg377 genes

Haplotype	Pfcrt	Pfmdr-1	dhfr	dhps	Pfg377 (bp deletions)	No. of isolates	% frequency
A1	76T	86Y	51I, 59R, 108N, 164L	436F, 437A, 540E, 581A, 613T	21, 63	1	0.8
A2	76T	86Y	51I, 59R, 108N, 164I	436F,437G, 540E, 581A, 613A	21, 63	1	0.8
A3	76T	86Y	51I, 59R, 108N, 164I	436F, 437A, 540E, 581A, 613A	21, 63	1	0.8
A4	76T	86Y	51I, 59R, 108N, 164I	436F, 437A, 540E, 581A, 613A	21	7	5.7
A5	76T	86Y	51N, 59R, 108S, 164I	436F, 437A, 540E, 581A, 613A	63	9	7.3
A6	76T	86Y	51N, 59C, 108S, 164I	436F, 537A, 540E, 581A, 613A	21, 63	1	0.8
A7	76T	86Y	51I, 59C, 108S, 164I	436F, 437A, 540K, 581A, 613A	83	1	0.8
A8	76T	86Y	51N, 59C, 108S, 164L	436S, 437A, 540K, 581A, 613A	63, 42, 83	1	0.8
A9	76T	86Y	51N, 59C, 108N, 164I	436S, 437A, 540K, 581A, 613A	21, 63, 42	2	1.6
A10	76T	86Y	51N, 59R, 108N, 164I	436F, 437A, 540K, 581E, 613A	21	21	17.2
A11	76T	86Y	51I, 59R, 108N, 164L	436F, 437G, 540E, 581A, 613A	21	8	6.5
A12	76T	86Y	51I, 59R, 108N, 164I	436F, 437A, 540E, 581G, 613A	21	5	4
A13	76T	86Y	51I, 59R, 108N, 164I	436F, 437A, 540K, 581G, 613T	21	2	1.6
A14	76T	86Y	51I, 59C, 108N, 164I	436F, 437A, 540K, 581A, 613A	–	1	0.8
A15	76T	86Y	51N, 59C, 108S, 164I	436F, 437A, 540K, 581A, 613A	21	3	2.4
A16	76T	86Y	51N, 59C, 108S, 164I	436S, 437A, 540K, 581A, 613A	–	12	9.8
A17	76K	86Y	51N, 59C, 108S, 164I	436S, 437A, 540K, 581A, 613A	–	2	1.6
A18	76K	86N	51N, 59C, 108S, 164I	436S, 437A, 540K, 581A, 613A	–	44	36

A18 is the wild type haplotype (drug resistance genes) found in the studied isolates

ISSN: 1475-2875