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Table 1 Ki values for Plasmodium and human dUTPases and IC50s for intraerythrocytic stages of Plasmodium falciparum

From: Validation of Plasmodium falciparum dUTPase as the target of 5′-tritylated deoxyuridine analogues with anti-malarial activity

 Ki PfdUTPaseKi HsdUTPaseIC50 Pf3D7
Compound 14.73 ± 0.16 μM> 100 μM0.04 ± 0.01 μM
Compound 20.56 ± 0.08 μM12.24 ± 6.91 μM0.06 ± 0.01 μM
Compound 30.079 ± 0.022 μM> 100 μM0.12 ± 0.05 μM
Compound 40.61 ± 0.07 μM> 100 μM0.15 ± 0.03 μM
  1. Values are the average of three independent experiments ± standard errors