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Table 3 Univariable and multivariable linear regression models to assess the effect of IgGs to AMA-1 and MSP-1 on the cellular immune mediator concentrations and interaction with year

From: Changing plasma cytokine, chemokine and growth factor profiles upon differing malaria transmission intensities

Analyte

IgG to AMA-1

IgG to MSP-1

Univariable

Multivariable & interaction with year

Univariable

Multivariable & interaction with year

Coefficient (CI)

p-value

Coefficient (CI)

p-value

p-value Int

Coefficient (CI)

p-value

Coefficient (CI)

p-value

p-value Int

FGF

− 0.024 (− 0.048, 0)

0.047

− 0.068 (− 0.261, 0.125)

0.486

0.636

− 0.019 (− 0.036, − 0.002)

0.027

− 0.016 (− 0.162, 0.13)

0.829

0.996

IL-1β

− 0.026 (− 0.054, 0.002)

0.07

− 0.046 (− 0.235, 0.144)

0.636

0.658

− 0.02 (− 0.037, − 0.003)

0.022

0.004 (− 0.124, 0.132)

0.956

0.954

G-CSF

− 0.002 (− 0.009, 0.004)

0.419

− 0.046 (− 0.091, 0)

0.05

0.058

− 0.002 (− 0.006, 0.002)

0.359

− 0.026 (− 0.062, 0.009)

0.146

0.155

IL-10

− 0.009 (− 0.035, 0.017)

0.511

− 0.098 (− 0.29, 0.094)

0.315

0.331

0.001 (− 0.017, 0.02)

0.886

− 0.122 (− 0.272, 0.029)

0.112

0.086

IL-13

− 0.017 (− 0.02, − 0.007)

0.001*

− 0.029 (− 0.108, 0.05)

0.473

0.75

− 0.012 (− 0.019, − 0.004)

0.002*

0.002 (− 0.06, 0.063)

0.954

0.707

IL-6

− 0.024 (− 0.071, 0.024)

0.335

0.014 (− 0.235, 0.262)

0.914

0.984

− 0.033 (− 0.067, 0.001)

0.055

− 0.015 (− 0.22, 0.19)

0.888

0.837

IL-12

− 0.007 (− 0.012, − 0.002)

0.004*

− 0.045 (− 0.083, − 0.008)

0.018

0.042

− 0.003 (− 0.007, 0)

0.06

− 0.01 (− 0.041, 0.021)

0.531

0.639

RANTES

0.005 (0.001, 0.01)

0.014

0.015 (− 0.016, 0.047)

0.338

0.501

0.002 (− 0.001, 0.005)

0.124

− 0.004 (− 0.029, 0.021)

0.769

0.689

Eotaxin

− 0.011 (− 0.026, 0.004)

0.141

− 0.103 (− 0.216, 0.01)

0.075

0.106

− 0.005 (− 0.015, 0.006)

0.385

− 0.037 (− 0.126, 0.052)

0.414

0.458

IL-17

− 0.019 (− 0.058, 0.02)

0.331

0.043 (− 0.258, 0.344)

0.778

0.687

0.004 (− 0.024, 0.033)

0.778

− 0.135 (− 0.37, 0.099)

0.256

0.229

MIP-1α

0.005 (− 0.014, 0.025)

0.591

− 0.027 (− 0.13, 0.076)

0.611

0.427

− 0.008 (− 0.021, 0.006)

0.269

− 0.058 (− 0.141, 0.024)

0.166

0.122

GM-CSF

− 0.021 (− 0.083, 0.041)

0.5

− 0.616 (− 1.092, − 0.141)

0.011

0.013

− 0.017 (− 0.062, 0.028)

0.451

− 0.336 (− 0.747, 0.075)

0.109

0.113

MIP-1β

− 0.003 (− 0.021, 0.015)

0.76

− 0.03 (− 0.111, 0.051)

0.463

0.365

− 0.013 (− 0.026, − 0.001)

0.039

− 0.027 (− 0.092, 0.037)

0.409

0.385

MCP-1

− 0.00 (− 0.01, 0.005)

0.504

− 0.061 (− 0.11, − 0.012)

0.015

0.014

− 0.007 (− 0.012, − 0.001)

0.017

− 0.062 (− 0.1, − 0.024)

0.001*

0.002*

IL-15

− 0.004 (− 0.018, 0.011)

0.626

0.064 (− 0.051, 0.18)

0.272

0.245

0.003 (− 0.007, 0.013)

0.531

0.033 (− 0.058, 0.125)

0.475

0.518

EGF

− 0.01 (− 0.027, 0.008)

0.27

− 0.009 (− 0.141, 0.123)

0.889

0.959

− 0.006 (− 0.017, 0.005)

0.289

0.008 (− 0.087, 0.103)

0.871

0.852

IL-5

− 0.036 (− 0.081, 0.009)

0.121

− 0.11 (− 0.46, 0.241)

0.539

0.685

− 0.008 (− 0.041, 0.024)

0.613

− 0.285 (− 0.557, − 0.013)

0.04

0.048

HGF

− 0.005 (− 0.013, 0.002)

0.16

− 0.045 (− 0.099, 0.009)

0.101

0.129

− 0.001 (− 0.006, 0.004)

0.632

− 0.025 (− 0.067, 0.017)

0.237

0.212

VEGF

− 0.027 (− 0.049, − 0.005)

0.018

0.242 (0.111, 0.373)

<0.001*

<0.001*

− 0.022 (− 0.037, − 0.006)

0.006*

0.096 (− 0.011, 0.203)

0.078

0.055

IFN-γ

0.002 (− 0.009, 0.013)

0.747

− 0.014 (− 0.098, 0.069)

0.735

0.7

0.004 (− 0.004, 0.012)

0.31

− 0.033 (− 0.1, 0.034)

0.33

0.272

IFN-α

− 0.005 (− 0.012, 0.002)

0.194

− 0.09 (− 0.139, − 0.04)

<0.001*

0.001*

− 0.005 (− 0.009, 0)

0.067

− 0.068 (− 0.106, − 0.03)

0.001*

0.001*

IL-1RA

− 0.01 (− 0.018, − 0.003)

0.007*

0.025 (− 0.018, 0.068)

0.261

0.145

− 0.008 (− 0.013, − 0.002)

0.004*

0.034 (− 0.001, 0.07)

0.055

0.036

TNF

0.001 (− 0.029, 0.03)

0.953

− 0.056 (− 0.264, 0.151)

0.592

0.527

− 0.013 (− 0.034, 0.009)

0.242

− 0.089 (− 0.255, 0.077)

0.292

0.287

IL-2

0.006 (− 0.03, 0.042)

0.736

− 0.006 (− 0.29, 0.279)

0.968

0.936

0.018 (− 0.008, 0.043)

0.178

0.005 (− 0.221, 0.23)

0.969

0.907

IL-7

− 0.009 (− 0.024, 0.006)

0.249

− 0.027 (− 0.155, 0.102)

0.68

0.781

− 0.002 (− 0.014, 0.009)

0.678

0.082 (− 0.023, 0.186)

0.126

0.114

IP-10

− 0.037 (− 0.054, − 0.021)

<0.001*

− 0.087 (− 0.205, 0.032)

0.152

0.377

− 0.02 (− 0.031, − 0.008)

0.001*

− 0.07 (− 0.163, 0.024)

0.146

0.248

IL-2R

− 0.016 (− 0.024, − 0.009)

<0.001*

− 0.019 − 0.079, 0.04)

0.52

0.909

− 0.008 (− 0.013, − 0.002)

0.005*

0.008 (− 0.04, 0.055)

0.751

0.53

MIG

− 0.01 (− 0.021, 0.001)

0.079

− 0.086 (− 0.171, − 0.002)

0.046

0.072

− 0.003 (− 0.011, 0.005)

0.49

− 0.038 (− 0.106, 0.03)

0.275

0.293

IL-4

− 0.014 (− 0.031, 0.002)

0.085

− 0.118 (− 0.239, 0.003)

0.056

0.081

− 0.007 (− 0.019, 0.004)

0.201

− 0.08 (− 0.173, 0.013)

0.092

0.104

IL-8

0.006 (− 0.02, 0.031)

0.657

0.052 (− 0.073, 0.177)

0.413

0.595

− 0.016 (− 0.034, 0.003)

0.091

− 0.019 (− 0.118, 0.081)

0.712

0.644

  1. p-values < 0.05 are in italic
  2. * p-values < 0.05 after adjusted for multiple comparisons by the Benjamini–Hochberg approach