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Table 3 Univariable and multivariable linear regression models to assess the effect of IgGs to AMA-1 and MSP-1 on the cellular immune mediator concentrations and interaction with year

From: Changing plasma cytokine, chemokine and growth factor profiles upon differing malaria transmission intensities

AnalyteIgG to AMA-1IgG to MSP-1
UnivariableMultivariable & interaction with yearUnivariableMultivariable & interaction with year
Coefficient (CI)p-valueCoefficient (CI)p-valuep-value IntCoefficient (CI)p-valueCoefficient (CI)p-valuep-value Int
FGF− 0.024 (− 0.048, 0)0.047− 0.068 (− 0.261, 0.125)0.4860.636− 0.019 (− 0.036, − 0.002)0.027− 0.016 (− 0.162, 0.13)0.8290.996
IL-1β− 0.026 (− 0.054, 0.002)0.07− 0.046 (− 0.235, 0.144)0.6360.658− 0.02 (− 0.037, − 0.003)0.0220.004 (− 0.124, 0.132)0.9560.954
G-CSF− 0.002 (− 0.009, 0.004)0.419− 0.046 (− 0.091, 0)0.050.058− 0.002 (− 0.006, 0.002)0.359− 0.026 (− 0.062, 0.009)0.1460.155
IL-10− 0.009 (− 0.035, 0.017)0.511− 0.098 (− 0.29, 0.094)0.3150.3310.001 (− 0.017, 0.02)0.886− 0.122 (− 0.272, 0.029)0.1120.086
IL-13− 0.017 (− 0.02, − 0.007)0.001*− 0.029 (− 0.108, 0.05)0.4730.75− 0.012 (− 0.019, − 0.004)0.002*0.002 (− 0.06, 0.063)0.9540.707
IL-6− 0.024 (− 0.071, 0.024)0.3350.014 (− 0.235, 0.262)0.9140.984− 0.033 (− 0.067, 0.001)0.055− 0.015 (− 0.22, 0.19)0.8880.837
IL-12− 0.007 (− 0.012, − 0.002)0.004*− 0.045 (− 0.083, − 0.008)0.0180.042− 0.003 (− 0.007, 0)0.06− 0.01 (− 0.041, 0.021)0.5310.639
RANTES0.005 (0.001, 0.01)0.0140.015 (− 0.016, 0.047)0.3380.5010.002 (− 0.001, 0.005)0.124− 0.004 (− 0.029, 0.021)0.7690.689
Eotaxin− 0.011 (− 0.026, 0.004)0.141− 0.103 (− 0.216, 0.01)0.0750.106− 0.005 (− 0.015, 0.006)0.385− 0.037 (− 0.126, 0.052)0.4140.458
IL-17− 0.019 (− 0.058, 0.02)0.3310.043 (− 0.258, 0.344)0.7780.6870.004 (− 0.024, 0.033)0.778− 0.135 (− 0.37, 0.099)0.2560.229
MIP-1α0.005 (− 0.014, 0.025)0.591− 0.027 (− 0.13, 0.076)0.6110.427− 0.008 (− 0.021, 0.006)0.269− 0.058 (− 0.141, 0.024)0.1660.122
GM-CSF− 0.021 (− 0.083, 0.041)0.5− 0.616 (− 1.092, − 0.141)0.0110.013− 0.017 (− 0.062, 0.028)0.451− 0.336 (− 0.747, 0.075)0.1090.113
MIP-1β− 0.003 (− 0.021, 0.015)0.76− 0.03 (− 0.111, 0.051)0.4630.365− 0.013 (− 0.026, − 0.001)0.039− 0.027 (− 0.092, 0.037)0.4090.385
MCP-1− 0.00 (− 0.01, 0.005)0.504− 0.061 (− 0.11, − 0.012)0.0150.014− 0.007 (− 0.012, − 0.001)0.017− 0.062 (− 0.1, − 0.024)0.001*0.002*
IL-15− 0.004 (− 0.018, 0.011)0.6260.064 (− 0.051, 0.18)0.2720.2450.003 (− 0.007, 0.013)0.5310.033 (− 0.058, 0.125)0.4750.518
EGF− 0.01 (− 0.027, 0.008)0.27− 0.009 (− 0.141, 0.123)0.8890.959− 0.006 (− 0.017, 0.005)0.2890.008 (− 0.087, 0.103)0.8710.852
IL-5− 0.036 (− 0.081, 0.009)0.121− 0.11 (− 0.46, 0.241)0.5390.685− 0.008 (− 0.041, 0.024)0.613− 0.285 (− 0.557, − 0.013)0.040.048
HGF− 0.005 (− 0.013, 0.002)0.16− 0.045 (− 0.099, 0.009)0.1010.129− 0.001 (− 0.006, 0.004)0.632− 0.025 (− 0.067, 0.017)0.2370.212
VEGF− 0.027 (− 0.049, − 0.005)0.0180.242 (0.111, 0.373)<0.001*<0.001*− 0.022 (− 0.037, − 0.006)0.006*0.096 (− 0.011, 0.203)0.0780.055
IFN-γ0.002 (− 0.009, 0.013)0.747− 0.014 (− 0.098, 0.069)0.7350.70.004 (− 0.004, 0.012)0.31− 0.033 (− 0.1, 0.034)0.330.272
IFN-α− 0.005 (− 0.012, 0.002)0.194− 0.09 (− 0.139, − 0.04)<0.001*0.001*− 0.005 (− 0.009, 0)0.067− 0.068 (− 0.106, − 0.03)0.001*0.001*
IL-1RA− 0.01 (− 0.018, − 0.003)0.007*0.025 (− 0.018, 0.068)0.2610.145− 0.008 (− 0.013, − 0.002)0.004*0.034 (− 0.001, 0.07)0.0550.036
TNF0.001 (− 0.029, 0.03)0.953− 0.056 (− 0.264, 0.151)0.5920.527− 0.013 (− 0.034, 0.009)0.242− 0.089 (− 0.255, 0.077)0.2920.287
IL-20.006 (− 0.03, 0.042)0.736− 0.006 (− 0.29, 0.279)0.9680.9360.018 (− 0.008, 0.043)0.1780.005 (− 0.221, 0.23)0.9690.907
IL-7− 0.009 (− 0.024, 0.006)0.249− 0.027 (− 0.155, 0.102)0.680.781− 0.002 (− 0.014, 0.009)0.6780.082 (− 0.023, 0.186)0.1260.114
IP-10− 0.037 (− 0.054, − 0.021)<0.001*− 0.087 (− 0.205, 0.032)0.1520.377− 0.02 (− 0.031, − 0.008)0.001*− 0.07 (− 0.163, 0.024)0.1460.248
IL-2R− 0.016 (− 0.024, − 0.009)<0.001*− 0.019 − 0.079, 0.04)0.520.909− 0.008 (− 0.013, − 0.002)0.005*0.008 (− 0.04, 0.055)0.7510.53
MIG− 0.01 (− 0.021, 0.001)0.079− 0.086 (− 0.171, − 0.002)0.0460.072− 0.003 (− 0.011, 0.005)0.49− 0.038 (− 0.106, 0.03)0.2750.293
IL-4− 0.014 (− 0.031, 0.002)0.085− 0.118 (− 0.239, 0.003)0.0560.081− 0.007 (− 0.019, 0.004)0.201− 0.08 (− 0.173, 0.013)0.0920.104
IL-80.006 (− 0.02, 0.031)0.6570.052 (− 0.073, 0.177)0.4130.595− 0.016 (− 0.034, 0.003)0.091− 0.019 (− 0.118, 0.081)0.7120.644
  1. p-values < 0.05 are in italic
  2. * p-values < 0.05 after adjusted for multiple comparisons by the Benjamini–Hochberg approach