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Table 4 Effect of parasite density (qPCR) on cellular immune mediators concentrations and interaction with year

From: Changing plasma cytokine, chemokine and growth factor profiles upon differing malaria transmission intensities

AnalyteParasite density by qPCR
Coefficient (CI)p-valuep-value BHp-value interactionp-value interaction BH
IL-1β− 0.076 (− 0.186, 0.034)0.1760.3770.2960.902
IL-1RA0.002 (− 0.053, 0.057)0.9450.9450.1430.860
TNF− 0.072 (− 0.149, 0.006)0.0690.2070.7640.916
IL-60.017 (− 0.122, 0.157)0.8050.8940.2740.902
IFN-α− 0.015 (− 0.041, 0.011)0.2520.4720.8830.916
IFN-γ− 0.025 (− 0.049, − 0.001)0.0450.1510.4700.916
IL-120.03 (0.007, 0.053)0.0100.0760.8940.916
IL-17− 0.046 (− 0.1, 0.008)0.0970.2660.4090.916
IL-100.157 (0.098, 0.216)< 0.001<0.001<0.0010.002
IL-13− 0.057 (− 0.095, − 0.018)0.0040.0400.7720.916
IL-4− 0.029 (− 0.074, 0.016)0.2070.4140.9120.916
IL-5− 0.07 (− 0.126, − 0.014)0.0150.0900.5150.916
IL-2− 0.022 (− 0.066, 0.023)0.3380.5900.7530.916
IL-2R0.053 (0.021, 0.085)0.0010.0180.8980.916
IL-15− 0.016 (− 0.063, 0.031)0.5060.7320.8190.916
IL-7− 0.193 (− 0.354, − 0.032)0.0190.0940.7850.916
Eotaxin− 0.04 (− 0.079, − 0.002)0.0400.1480.1790.896
IL-8− 0.053 (− 0.18, 0.075)0.4140.6530.3010.902
IP-100.024 (− 0.027, 0.074)0.3540.5900.7990.916
MCP10.041 (0.002, 0.081)0.0390.1480.4430.916
MIG0.035 (− 0.011, 0.081)0.1340.3340.2760.902
MIP-1α− 0.027 (− 0.128, 0.074)0.5940.7420.5000.916
MIP-1β− 0.004 (− 0.107, 0.098)0.9330.9450.0930.697
RANTES− 0.01 (− 0.044, 0.024)0.5610.7320.8960.916
EGF− 0.015 (− 0.089, 0.059)0.6830.8200.9160.916
FGF− 0.007 (− 0.125, 0.112)0.9110.9450.7340.916
G-CSF− 0.009 (− 0.035, 0.018)0.5220.7320.3660.916
GM-CSF− 0.05 (− 0.117, 0.018)0.1470.3390.0280.424
HGF0.007 (− 0.035, 0.049)0.7330.8460.7120.916
VEGF0.023 (− 0.055, 0.101)0.5600.7320.0760.697
  1. The effect of parasite density on analytes concentrations was assessed through multivariable linear regressions for each analyte, with analyte concentration as outcome (pg/mL) and parasitaemia as the predictor variable. Interaction tests were performed to determine if there was an interaction of parasite density with year on the analyte levels. BH: p-values adjusted for multiple testing by Benjamini–Hochberg
  2. P-values < 0.05 are in italic
  3. CI confidence intervals