Changing plasma cytokine, chemokine and growth factor profiles upon differing malaria transmission intensities

Aguilar, Ruth; Campo, Joseph J.; Chicuecue, Silvia; Cisteró, Pau; Català, Alba; Luis, Leopoldina; Ubillos, Itziar; Galatas, Beatriz; Aide, Pedro; Guinovart, Caterina; Moncunill, Gemma; Dobaño, Carlota

doi:10.1186/s12936-019-3038-x

Malaria Journal

Table 4 Effect of parasite density (qPCR) on cellular immune mediators concentrations and interaction with year

From: Changing plasma cytokine, chemokine and growth factor profiles upon differing malaria transmission intensities

Analyte	Parasite density by qPCR
Analyte	Coefficient (CI)	p-value	p-value BH	p-value interaction	p-value interaction BH
IL-1β	− 0.076 (− 0.186, 0.034)	0.176	0.377	0.296	0.902
IL-1RA	0.002 (− 0.053, 0.057)	0.945	0.945	0.143	0.860
TNF	− 0.072 (− 0.149, 0.006)	0.069	0.207	0.764	0.916
IL-6	0.017 (− 0.122, 0.157)	0.805	0.894	0.274	0.902
IFN-α	− 0.015 (− 0.041, 0.011)	0.252	0.472	0.883	0.916
IFN-γ	− 0.025 (− 0.049, − 0.001)	0.045	0.151	0.470	0.916
IL-12	0.03 (0.007, 0.053)	0.010	0.076	0.894	0.916
IL-17	− 0.046 (− 0.1, 0.008)	0.097	0.266	0.409	0.916
IL-10	0.157 (0.098, 0.216)	< 0.001	<0.001	<0.001	0.002
IL-13	− 0.057 (− 0.095, − 0.018)	0.004	0.040	0.772	0.916
IL-4	− 0.029 (− 0.074, 0.016)	0.207	0.414	0.912	0.916
IL-5	− 0.07 (− 0.126, − 0.014)	0.015	0.090	0.515	0.916
IL-2	− 0.022 (− 0.066, 0.023)	0.338	0.590	0.753	0.916
IL-2R	0.053 (0.021, 0.085)	0.001	0.018	0.898	0.916
IL-15	− 0.016 (− 0.063, 0.031)	0.506	0.732	0.819	0.916
IL-7	− 0.193 (− 0.354, − 0.032)	0.019	0.094	0.785	0.916
Eotaxin	− 0.04 (− 0.079, − 0.002)	0.040	0.148	0.179	0.896
IL-8	− 0.053 (− 0.18, 0.075)	0.414	0.653	0.301	0.902
IP-10	0.024 (− 0.027, 0.074)	0.354	0.590	0.799	0.916
MCP1	0.041 (0.002, 0.081)	0.039	0.148	0.443	0.916
MIG	0.035 (− 0.011, 0.081)	0.134	0.334	0.276	0.902
MIP-1α	− 0.027 (− 0.128, 0.074)	0.594	0.742	0.500	0.916
MIP-1β	− 0.004 (− 0.107, 0.098)	0.933	0.945	0.093	0.697
RANTES	− 0.01 (− 0.044, 0.024)	0.561	0.732	0.896	0.916
EGF	− 0.015 (− 0.089, 0.059)	0.683	0.820	0.916	0.916
FGF	− 0.007 (− 0.125, 0.112)	0.911	0.945	0.734	0.916
G-CSF	− 0.009 (− 0.035, 0.018)	0.522	0.732	0.366	0.916
GM-CSF	− 0.05 (− 0.117, 0.018)	0.147	0.339	0.028	0.424
HGF	0.007 (− 0.035, 0.049)	0.733	0.846	0.712	0.916
VEGF	0.023 (− 0.055, 0.101)	0.560	0.732	0.076	0.697

The effect of parasite density on analytes concentrations was assessed through multivariable linear regressions for each analyte, with analyte concentration as outcome (pg/mL) and parasitaemia as the predictor variable. Interaction tests were performed to determine if there was an interaction of parasite density with year on the analyte levels. BH: p-values adjusted for multiple testing by Benjamini–Hochberg
P-values < 0.05 are in italic
CI confidence intervals

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ISSN: 1475-2875

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