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Table 5 Effect of 2013 compared to 2010 on analyte concentrations in infected and uninfected individuals

From: Changing plasma cytokine, chemokine and growth factor profiles upon differing malaria transmission intensities

Analytes

Coefficient (CI)

p-value

p-value BH

Coefficient (CI) adjusted

p-value adjusted*

p-value BH adjusted*

Infected

 IL-1β

− 1.248 (− 1.463, − 1.034)

< 0.001

< 0.001

− 1.311 (− 1.543, − 1.079)

< 0.001

< 0.001

 IL-1RA

− 0.638 (− 0.743, − 0.534)

< 0.001

< 0.001

− 0.67 (− 0.781, − 0.559)

< 0.001

< 0.001

 TNF

− 0.666 (− 0.842, − 0.49)

< 0.001

< 0.001

− 0.678 (− 0.867, − 0.489)

< 0.001

< 0.001

 IL-6

− 1.945 (− 2.144, − 1.746)

< 0.001

< 0.001

− 2.023 (− 2.239, − 1.807)

< 0.001

< 0.001

 IFN-α

− 0.025 (− 0.093, 0.043)

0.470

0.486

− 0.026 (− 0.097, 0.046)

0.481

0.505

 IFN-γ

− 0.036 (− 0.099, 0.028)

0.268

0.321

− 0.039 (− 0.103, 0.026)

0.235

0.293

 IL-12

− 0.035 (− 0.096, 0.027)

0.265

0.321

− 0.029 (− 0.092, 0.033)

0.358

0.410

 IL-17

− 0.147 (− 0.288, − 0.006)

0.041

0.057

− 0.149 (− 0.295, − 0.002)

0.047

0.064

 IL-10

− 0.227 (− 0.391, − 0.063)

0.007

0.010

− 0.235 (− 0.407, − 0.063)

0.008

0.012

 IL-13

− 0.119 (− 0.22, − 0.017)

0.022

0.031

− 0.149 (− 0.252, − 0.046)

0.005

0.009

 IL-4

− 0.076 (− 0.193, 0.042)

0.205

0.267

− 0.073 (− 0.196, 0.051)

0.245

0.295

 IL-5

− 0.018 (− 0.167, 0.132)

0.815

0.815

− 0.033 (− 0.187, 0.121)

0.673

0.673

 IL-2

− 0.064 (− 0.181, 0.052)

0.278

0.321

− 0.056 (− 0.177, 0.066)

0.369

0.410

 IL-2R

− 0.126 (− 0.21, − 0.042)

0.003

0.006

− 0.123 (− 0.202, − 0.043)

0.003

0.005

 IL-15

− 0.182 (− 0.302, − 0.063)

0.003

0.006

− 0.168 (− 0.294, − 0.043)

0.009

0.013

 IL-7

− 0.819 (− 1.228, − 0.411)

< 0.001

< 0.001

− 0.858 (− 1.279, − 0.436)

< 0.001

< 0.001

 Eotaxin

− 0.043 (− 0.145, 0.058)

0.401

0.430

− 0.066 (− 0.173, 0.04)

0.221

0.288

 IL-8

− 1.769 (− 1.956, − 1.582)

< 0.001

< 0.001

− 1.868 (− 2.067, − 1.669)

< 0.001

< 0.001

 IP-10

− 0.242 (− 0.369, − 0.116)

< 0.001

0.001

− 0.227 (− 0.36, − 0.094)

0.001

0.002

 MCP1

− 0.29 (− 0.384, − 0.196)

< 0.001

< 0.001

− 0.284 (− 0.385, − 0.182)

< 0.001

< 0.001

 MIG

− 0.061 (− 0.181, 0.059)

0.313

0.348

− 0.044 (− 0.169, 0.081)

0.488

0.505

 MIP-1α

− 1.14 (− 1.335, − 0.946)

< 0.001

< 0.001

− 1.2 (− 1.41, − 0.991)

< 0.001

< 0.001

 MIP-1β

− 1.413 (− 1.565, − 1.26)

< 0.001

< 0.001

− 1.454 (− 1.622, − 1.287)

< 0.001

< 0.001

 RANTES

0.143 (0.056, 0.23)

0.001

0.003

0.109 (0.018, 0.201)

0.019

0.027

 EGF

− 0.61 (− 0.778, − 0.442)

< 0.001

< 0.001

− 0.684 (− 0.858, − 0.511)

< 0.001

< 0.001

 FGF

− 0.754 (− 1.04, − 0.467)

< 0.001

< 0.001

− 0.935 (− 1.222, − 0.648)

< 0.001

< 0.001

 G-CSF

− 0.1 (− 0.169, − 0.032)

0.004

0.006

− 0.096 (− 0.167, − 0.026)

0.008

0.012

 GM-CSF

− 0.291 (− 0.462, − 0.12)

0.001

0.002

− 0.345 (− 0.524, − 0.167)

< 0.001

< 0.001

 HGF

− 0.16 (− 0.268, − 0.053)

0.004

0.006

− 0.154 (− 0.261, − 0.046)

0.005

0.009

 VEGF

− 0.913 (− 1.057, − 0.769)

< 0.001

< 0.001

− 0.967 (− 1.118, − 0.816)

< 0.001

< 0.001

Uninfected

 IL-1β

− 2.586 (− 2.949, − 2.223)

< 0.001

< 0.001

− 2.551 (− 2.961, − 2.14)

< 0.001

< 0.001

 IL-1RA

− 0.501 (− 0.597, − 0.406)

< 0.001

< 0.001

− 0.523 (− 0.628, − 0.418)

< 0.001

< 0.001

 TNF

− 0.684 (− 0.877, − 0.49)

< 0.001

< 0.001

− 0.699 (− 0.917, − 0.48)

< 0.001

< 0.001

 IL-6

− 2.876 (− 3.129, − 2.623)

< 0.001

< 0.001

− 2.878 (− 3.162, − 2.595)

< 0.001

< 0.001

 IFN-α

− 0.291 (− 0.344, − 0.239)

< 0.001

< 0.001

− 0.288 (− 0.347, − 0.23)

< 0.001

< 0.001

 IFN-γ

0.002 (− 0.076, 0.08)

0.960

0.960

− 0.001 (− 0.087, 0.085)

0.975

0.975

 IL-12

− 0.129 (− 0.19, − 0.068)

< 0.001

< 0.001

− 0.158 (− 0.217, − 0.098)

< 0.001

< 0.001

 IL-17

0.072 (− 0.085, 0.228)

0.369

0.410

0.054 (− 0.121, 0.229)

0.544

0.628

 IL-10

− 0.391 (− 0.53, − 0.251)

< 0.001

< 0.001

− 0.376 (− 0.532, − 0.221)

< 0.001

< 0.001

 IL-13

− 0.264 (− 0.404, − 0.123)

< 0.001

< 0.001

− 0.272 (− 0.432, − 0.112)

0.001

0.001

 IL-4

− 0.245 (− 0.342, − 0.148)

< 0.001

< 0.001

− 0.233 (− 0.34, − 0.125)

< 0.001

< 0.001

 IL-5

0.046 (− 0.086, 0.178)

0.493

0.510

0.066 (− 0.083, 0.215)

0.386

0.464

 IL-2

0.076 (− 0.13, 0.282)

0.467

0.501

0.012 (− 0.201, 0.224)

0.914

0.946

 IL-2R

− 0.12 (− 0.247, 0.007)

0.064

0.087

− 0.195 (− 0.319, − 0.072)

0.002

0.003

 IL-15

− 0.22 (− 0.546, 0.106)

0.184

0.224

− 0.356 (− 0.711, − 0.001)

0.050

0.062

 IL-7

− 0.868 (− 1.188, − 0.549)

< 0.001

< 0.001

− 0.917 (− 1.264, − 0.579)

< 0.001

< 0.001

 Eotaxin

− 0.081 (− 0.177, 0.015)

0.099

0.129

0.011 (− 0.089, 0.112)

0.824

0.883

 IL-8

− 2.096 (− 2.287, − 1.904)

< 0.001

< 0.001

− 2.127 (− 2.339, − 1.916)

< 0.001

< 0.001

 IP-10

− 0.343 (− 0.436, − 0.25)

< 0.001

< 0.001

− 0.337 (− 0.441, − 0.233)

< 0.001

< 0.001

 MCP1

− 0.527 (− 0.615, − 0.44)

< 0.001

< 0.001

− 0.515 (− 0.614, − 0.416)

< 0.001

< 0.001

 MIG

− 0.076 (− 0.215, 0.062)

0.279

0.322

− 0.033 (− 0.186, 0.12)

0.673

0.748

 MIP-1α

− 1.267 (− 1.442, − 1.093)

< 0.001

< 0.001

− 1.299 (− 1.497, − 1.101)

< 0.001

< 0.001

 MIP-1β

− 1.484 (− 1.629, − 1.349

< 0.001

< 0.001

− 1.478 (− 1.638, − 1.319)

< 0.001

< 0.001

 RANTES

0.129 (0.05, 0.209)

0.002

0.002

0.164 (0.087, 0.241)

< 0.001

< 0.001

 EGF

− 1.555 (− 1.855, − 1.255)

< 0.001

< 0.001

− 1.682 (− 2.004, − 1.359)

< 0.001

< 0.001

 FGF

− 0.201 (− 0.499, 0.098)

0.187

0.224

− 0.336 (− 0.662,− 0.011)

0.043

0.056

 G-CSF

− 0.211 (− 0.307, − 0.114)

< 0.001

< 0.001

− 0.236 (− 0.341, − 0.131)

< 0.001

< 0.001

 GM-CSF

− 0.195 (− 0.354, − 0.036)

0.017

0.024

− 0.195 (0.374, − 0.016)

0.033

0.045

 HGF

− 0.29 (− 0.364, − 0.215)

< 0.001

< 0.001

− 0.305 (− 0.386, − 0.225)

< 0.001

< 0.001

 VEGF

− 1.887 (− 2.159, − 1.614)

< 0.001

< 0.001

− 1.938 (− 2.235, − 1.641)

< 0.001

< 0.001

  1. The effect of year on analyte concentrations was assessed through univariable l and multivariable (adjusted models) separate linear regressions for each analyte, with analyte concentration (pg/mL) as outcome and year (2013 vs 2010) as the predictor variable. The analysis is presented separately for the infected and uninfected subjects. BH: P-values adjusted for multiple testing by Benjamini–Hochberg
  2. P-values < 0.05 are in italic
  3. CI confidence intervals
  4. * Adjusted by age group and area