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Table 2 In vitro anti-malarial activity of the chalcones on P. falciparum chloroquineS and P. falciparum chloroquineR strains, their HeLa cell cytotoxicity and resistance (RI) and selectivity indices (SI)

From: In vitro anti-malarial efficacy of chalcones: cytotoxicity profile, mechanism of action and their effect on erythrocytes

Compounds/drugs codeP. falciparum
Chloroquines
Strain (MRC-2) IC50 (µg/mL)
P. falciparum
Chloroquines
Strain (MRC-2) IC90 (µg/mL)
P. falciparum
ChloroquineR
Strain (RKL-9) IC50 (µg/mL)
P. falciparum
ChloroquineR
Strain (RKL-9) IC90 (µg/mL)
Resistance Index (RI)
IC50 (RKL-9)/IC50 (MRC-2)
HeLa Cell
CC50
Selective index (SI)
P.falciparum chloroquines (MRC-2)
Selective index (SI)
P.falciparum chloroquineR (RKL-9)
10.345.540.231.420.684.3612.8218.96
20.130.510.140.361.081.068.157.57
30.170.750.291.151.717.7945.8226.86
40.150.400.512.263.400.845.601.65
50.161.080.230.921.438.4552.8136.74
60.355.230.190.980.541.664.748.74
70.110.460.180.671.6415.31139.1885.05
80.291.010.265.310.902.207.598.46
90.250.960.210.950.841.656.607.85
100.200.890.190.810.951.889.409.90
CHL0.171.1431.04182.58
QNN0.251.5930.31121.24
ART (ng/mL)0.150.1549.11327.4
  1. ChloroquineS = Chloroquine Sensitive and ChloroquineR = Chloroquine Resistant
  2. CHL chloroquine, QNN quinine hydrochloride, ART artemisinin