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Table 2 In vitro anti-malarial activity of the chalcones on P. falciparum chloroquineS and P. falciparum chloroquineR strains, their HeLa cell cytotoxicity and resistance (RI) and selectivity indices (SI)

From: In vitro anti-malarial efficacy of chalcones: cytotoxicity profile, mechanism of action and their effect on erythrocytes

Compounds/drugs code

P. falciparum

Chloroquines

Strain (MRC-2) IC50 (µg/mL)

P. falciparum

Chloroquines

Strain (MRC-2) IC90 (µg/mL)

P. falciparum

ChloroquineR

Strain (RKL-9) IC50 (µg/mL)

P. falciparum

ChloroquineR

Strain (RKL-9) IC90 (µg/mL)

Resistance Index (RI)

IC50 (RKL-9)/IC50 (MRC-2)

HeLa Cell

CC50

Selective index (SI)

P.falciparum chloroquines (MRC-2)

Selective index (SI)

P.falciparum chloroquineR (RKL-9)

1

0.34

5.54

0.23

1.42

0.68

4.36

12.82

18.96

2

0.13

0.51

0.14

0.36

1.08

1.06

8.15

7.57

3

0.17

0.75

0.29

1.15

1.71

7.79

45.82

26.86

4

0.15

0.40

0.51

2.26

3.40

0.84

5.60

1.65

5

0.16

1.08

0.23

0.92

1.43

8.45

52.81

36.74

6

0.35

5.23

0.19

0.98

0.54

1.66

4.74

8.74

7

0.11

0.46

0.18

0.67

1.64

15.31

139.18

85.05

8

0.29

1.01

0.26

5.31

0.90

2.20

7.59

8.46

9

0.25

0.96

0.21

0.95

0.84

1.65

6.60

7.85

10

0.20

0.89

0.19

0.81

0.95

1.88

9.40

9.90

CHL

0.17

1.14

–

–

–

31.04

182.58

–

QNN

–

–

0.25

1.59

–

30.31

–

121.24

ART (ng/mL)

–

–

0.15

0.15

–

49.11

–

327.4

  1. ChloroquineS = Chloroquine Sensitive and ChloroquineR = Chloroquine Resistant
  2. CHL chloroquine, QNN quinine hydrochloride, ART artemisinin