Compounds/drugs code | P. falciparum Chloroquines Strain (MRC-2) IC50 (µg/mL) | P. falciparum Chloroquines Strain (MRC-2) IC90 (µg/mL) | P. falciparum ChloroquineR Strain (RKL-9) IC50 (µg/mL) | P. falciparum ChloroquineR Strain (RKL-9) IC90 (µg/mL) | Resistance Index (RI) IC50 (RKL-9)/IC50 (MRC-2) | HeLa Cell CC50 | Selective index (SI) P.falciparum chloroquines (MRC-2) | Selective index (SI) P.falciparum chloroquineR (RKL-9) |
---|---|---|---|---|---|---|---|---|
1 | 0.34 | 5.54 | 0.23 | 1.42 | 0.68 | 4.36 | 12.82 | 18.96 |
2 | 0.13 | 0.51 | 0.14 | 0.36 | 1.08 | 1.06 | 8.15 | 7.57 |
3 | 0.17 | 0.75 | 0.29 | 1.15 | 1.71 | 7.79 | 45.82 | 26.86 |
4 | 0.15 | 0.40 | 0.51 | 2.26 | 3.40 | 0.84 | 5.60 | 1.65 |
5 | 0.16 | 1.08 | 0.23 | 0.92 | 1.43 | 8.45 | 52.81 | 36.74 |
6 | 0.35 | 5.23 | 0.19 | 0.98 | 0.54 | 1.66 | 4.74 | 8.74 |
7 | 0.11 | 0.46 | 0.18 | 0.67 | 1.64 | 15.31 | 139.18 | 85.05 |
8 | 0.29 | 1.01 | 0.26 | 5.31 | 0.90 | 2.20 | 7.59 | 8.46 |
9 | 0.25 | 0.96 | 0.21 | 0.95 | 0.84 | 1.65 | 6.60 | 7.85 |
10 | 0.20 | 0.89 | 0.19 | 0.81 | 0.95 | 1.88 | 9.40 | 9.90 |
CHL | 0.17 | 1.14 | – | – | – | 31.04 | 182.58 | – |
QNN | – | – | 0.25 | 1.59 | – | 30.31 | – | 121.24 |
ART (ng/mL) | – | – | 0.15 | 0.15 | – | 49.11 | – | 327.4 |