Fig. 4

Isobolograms of controls and selected Malaria Box compounds. a Atovaquone with proguanil and b artesunate with itself were used as controls for synergic and additive profiles, respectively. c–m Isobolograms of the 11 selected compounds in combination with artesunate. Black lines and grey areas indicate the arithmetic averages and standard deviations of the upper and lower limits of the additive area, respectively. Red dots indicate the experimental determination of the FIC₅₀ pairs