Fig. 5
Histological scores of mouse spleen (a), brain (b), liver (c), heart (d), lung (e) and kidney (f) in uninfected mice and P. berghei infected mice following IL-35 modulation. Ctrl + PBS = uninfected + Phosphate buffered saline; M + PBS = P. berghei + Phosphate buffered saline; M + IgG = P. berghei + immunoglobulin G antibody; M + rIL-35 = P. berghei + recombinant IL-35 protein; M + AEBI3 = P. berghei + neutralizing anti Epstein Barr virus induced protein-3 antibody. Significant differences in histological scores (**p < 0.001) were observed between infected mice treated with neutralizing AEBI3 antibody and mice treated with IgG antibody. Data are mean ± sem (n = 6), Data shown is a representative from three experiments