Fig. 3
From: An in vitro toolbox to accelerate anti-malarial drug discovery and development
Relationship between a FaSSIF solubility (grey bar represents the maximum solubility range assessed), b Caco-2 permeability (circled symbols represent compounds with high efflux ratios), c fraction unbound in plasma, and d unbound intrinsic clearance (open symbols represent “less than” values) and measured Log D7.4. Where measured Log D values were not available, calculated (ADMET Predictor) values were used. Symbols represent data for development (green) and legacy (blue) anti-malarial compounds. Caco-2 Papp data for chloroquine, quinine, amodiaquine, naphthoquine, mefloquine, piperaquine, atovaquone and halofantrine are from Katneni et al. [31]