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Table 3 Performance characteristics of two malaria rapid diagnostic tests, Magaria, Niger, 2017–2018

From: Clinical diagnostic evaluation of HRP2 and pLDH-based rapid diagnostic tests for malaria in an area receiving seasonal malaria chemoprevention in Niger

Characteristic

High transmission season

Low transmission season

Test

Na

Value

95% CI

Na

Value

95% CI

Sensitivity

 pLDH

246

99.2

97.0–99.9

155

91.0

85.3–95.0

 HRP2

246

99.2

97.1–99.9

155

85.8

79.3–90.9

Specificity

 pLDH

293

58.0

52.1–63.8

1252

92.6

91.1–94.0

 HRP2

293

57.4

51.5–63.1

1252

93.5

91.9–94.8

PPV

 pLDH

361

66.3

61.1–71.2

233

60.5

53.9–66.8

 HRP2

370

66.3

61.2–71.1

215

61.9

55.0–68.4

NPV

 pLDH

169

98.8

95.8–99.9

1173

98.8

98.0–99.3

 HRP2

169

98.8

95.8–99.9

1192

98.2

97.2–98.8

  1. PPV positive predictive value, NPV negative predictive value
  2. aFor sensitivity, N represents all microscopy-positives; for specificity, N represents all microscopy-negatives; for PPV, N represents all test positives; and for NPV, N represents all test negatives
  3. Exact McNemar test p = 0.008