TY - JOUR AU - Dadgar Pakdel, Javad AU - Zakeri, Sedigheh AU - Raz, Abbasali AU - Dinparast Djadid, Navid PY - 2020 DA - 2020/02/19 TI - Identification, molecular characterization and expression of aminopeptidase N-1 (APN-1) from Anopheles stephensi in SF9 cell line as a candidate molecule for developing a vaccine that interrupt malaria transmission JO - Malaria Journal SP - 79 VL - 19 IS - 1 AB - According to the World Health Organization reports, billions of people around the world are at risk for malaria disease and it is important to consider the preventive strategies for protecting the people that are living in high risk areas. One of the main reasons of disease survival is diversity of vectors and parasites in different malaria regions that have their specific features, behaviour and biology. Therefore, specific regional strategies are necessary for successful control of malaria. One of the tools that needs to be developed for elimination and prevention of reintroduction of malaria is a vaccine that interrupt malaria transmission (VIMTs). VIMT is a broad concept that should be adjusted to the biological characteristics of the disease in each region. One type of VIMT is a vector-based vaccine that affects the sexual stage of Plasmodium life cycle. According to recent studies, the aminopeptidase N-1 of Anopheles gambiae (AgAPN-1) is as a potent vector-based VIMT with considerable inhibition activity against the sexual stage of Plasmodium parasite. SN - 1475-2875 UR - https://doi.org/10.1186/s12936-020-03154-3 DO - 10.1186/s12936-020-03154-3 ID - Dadgar Pakdel2020 ER -