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Table 2 Polymorphisms in the pvdbp-II fragment of isolates from AF and BA regions

From: Extensive genetic diversity of Plasmodium vivax dbp-II in Rio de Janeiro Atlantic Forest and Brazilian Amazon Basin: evidence of positive selection

Codonsa

Sal-1b

Polymorphic sitesc

Isolates

AF (79) N (%)

BA (137) N (%)

Total (216) N (%)

N305Y

AAT

TAT

57 (72)

13 (9)

70 (32)

R308S

AGG

AGT

57 (72)

26 (19)

83 (38)

I322S

ATT

AGT

17 (22)

0

0

L333F

CTT

TTT

52 (66)

7 (5)

59 (27)

K371E

AAA

GAA

17 (22)

55 (40)

72 (33)

K371N

AAA

AAT

10 (13)

0

0

N375D

AAT

GAT

0

6 (4)

0

R378R

CGC

CGT

55 (70)

12 (9)

67 (31)

D384G

GAT

GGT

78 (99)

113 (82)

191 (88)

E385K

GAA

AAA

36 (46)

30 (22)

66 (30)

E385Q

GAA

CAA

21 (27)

0

0

E385T

GAA

ACA

3 (4)

0

0

K386Q

AAG

CAG

17 (22)

30 (22)

47 (22)

K386N

AAG

AAT

37 (47)

29 (21)

66 (30)

K386T

AAG

ACT

22 (28)

0

0

R390H

CGT

CAT

59 (75)

54 (39)

113 (52)

S398T

TCT

ACT

1 (1)

6 (4)

7 (3)

T404R

ACA

AGA

59 (75)

7 (5)

66 (30)

K411N

AAA

AAC

60 (76)

0

0

N417K

AAT

AAA

16 (20)

64 (47)

80 (37)

I419L

ATA

CTA

20 (25)

0

0

I419R

ATA

AGA

6 (8)

0

0

I419M

ATA

ATG

0

13 (9)

0

L424I

TTA

ATA

77 (97)

75 (55)

152 (70)

W437R

TGG

CGG

17 (22)

70 (51)

87 (40)

Q454P

CAA

CCA

8 (10)

12 (9)

20 (9)

Q486E

CAA

GAA

2 (2)

5 (4)

7 (3)

I503K

ATA

AAA

14 (18)

62 (45)

76 (35)

  1. aThe first letter represents the amino acid in Sal-1 reference sequence and the last the replacing amino acid
  2. bReference Salvador 1 strain
  3. ccharacters in bold and underlined correspond to nucleotide substitution relative to Sal-1 strain